Task-independent acute effects of delta-9-tetrahydrocannabinol on human brain function and its relationship with cannabinoid receptor gene expression: A neuroimaging meta-regression analysis.

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_1BBAB7FDA7B2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Task-independent acute effects of delta-9-tetrahydrocannabinol on human brain function and its relationship with cannabinoid receptor gene expression: A neuroimaging meta-regression analysis.
Périodique
Neuroscience and biobehavioral reviews
Auteur⸱e⸱s
Gunasekera B., Davies C., Blest-Hopley G., Veronese M., Ramsey N.F., Bossong M.G., Radua J., Bhattacharyya S.
Collaborateur⸱rice⸱s
CBE Consortium
Contributeur⸱rice⸱s
Pretzsch C., McAlonan G., Walter C., Lötsch J., Freeman T., Curran V., Battistella G., Fornari E., Filho G.B., Crippa J.A., Duran F., Zuardi A.W.
ISSN
1873-7528 (Electronic)
ISSN-L
0149-7634
Statut éditorial
Publié
Date de publication
09/2022
Peer-reviewed
Oui
Volume
140
Pages
104801
Langue
anglais
Notes
Publication types: Journal Article ; Review ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The neurobiological mechanisms underlying the effects of delta-9-tetrahydrocannabinol (THC) remain unclear. Here, we examined the spatial acute effect of THC on human regional brain activation or blood flow (hereafter called 'activation signal') in a 'core' network of brain regions from 372 participants, tested using a within-subject repeated measures design under experimental conditions. We also investigated whether the neuromodulatory effects of THC are related to the local expression of the cannabinoid-type-1 (CB1R) and type-2 (CB2R) receptors. Finally, we investigated the dose-response relationship between THC and key brain substrates. These meta-analytic findings shed new light on the localisation of the effects of THC in the human brain, suggesting that THC has neuromodulatory effects in regions central to many cognitive tasks and processes, related to dose, with greater effects in regions with higher levels of CB1R expression.
Mots-clé
Brain, Dronabinol, Gene Expression, Humans, Neuroimaging, Receptors, Cannabinoid, Regression Analysis, Attention, Cannabis, FMRI, Memory, Meta-analysis, PET, Reward, Systematic, THC, Tetrahydrocannabinol
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/08/2022 14:39
Dernière modification de la notice
25/11/2023 8:11
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