Allogeneic beta-islet cells correct diabetes and resist immune rejection.

Détails

ID Serval
serval:BIB_1BB20FF35B00
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Allogeneic beta-islet cells correct diabetes and resist immune rejection.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur⸱e⸱s
Pericin M., Althage A., Freigang S., Hengartner H., Rolland E., Dupraz P., Thorens B., Aebischer P., Zinkernagel R.M.
ISSN
0027-8424[print], 0027-8424[linking]
Statut éditorial
Publié
Date de publication
2002
Volume
99
Numéro
12
Pages
8203-8206
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Allogeneic MHC-incompatible organ or cell grafts are usually promptly rejected by immunocompetent hosts. Here we tested allogeneic beta-islet cell graft acceptance by immune or naive C57BL/6 mice rendered diabetic with streptozotocin (STZ). Fully MHC-mismatched insulin-producing growth-regulated beta-islet cells were transplanted under the kidney capsule or s.c. Although previously or simultaneously primed mice rejected grafts, STZ-treated diabetic mice accepted islet cell grafts, and hyperglycemia was corrected within 2-4 weeks in absence of conventional immunosuppression. Allogeneic grafts that controlled hyperglycemia expressed MHC antigens, were not rejected for >100 days, and resisted a challenge by allogeneic skin grafts or multiple injections of allogeneic cells. Importantly, the skin grafts were rejected in a primary fashion by the grafted and corrected host, indicating neither tolerization nor priming. Such strictly extralymphatic cell grafts that are immunologically largely ignored should be applicable clinically.
Mots-clé
Animals, Blood Glucose/metabolism, Diabetes Mellitus, Experimental/surgery, Graft Rejection/prevention &amp, control, Graft Survival/immunology, Graft Survival/physiology, Insulin/analysis, Islets of Langerhans Transplantation/immunology, Islets of Langerhans Transplantation/pathology, Major Histocompatibility Complex, Mice, Mice, Inbred C3H, Mice, Inbred C57BL, Skin Transplantation/immunology, Time Factors, Transplantation, Homologous
Pubmed
Web of science
Création de la notice
24/01/2008 13:41
Dernière modification de la notice
20/08/2019 12:52
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