Perinatal nitric oxide therapy prevents adverse effects of perinatal hypoxia on the adult pulmonary circulation.

Détails

Ressource 1Télécharger: BIB_1B852254F8A1.P001.pdf (751.99 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_1B852254F8A1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Perinatal nitric oxide therapy prevents adverse effects of perinatal hypoxia on the adult pulmonary circulation.
Périodique
Biomed Research International
Auteur(s)
Peyter A.C., Delhaes F., Diaceri G., Menétrey S., Tolsa J.F.
ISSN
2314-6141 (Electronic)
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Pages
949361
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Adverse events in utero are associated with the occurrence of chronic diseases in adulthood. We previously demonstrated in mice that perinatal hypoxia resulted in altered pulmonary circulation in adulthood, with a decreased endothelium-dependent relaxation of pulmonary arteries, associated with long-term alterations in the nitric oxide (NO)/cyclic GMP pathway. The present study investigated whether inhaled NO (iNO) administered simultaneously to perinatal hypoxia could have potential beneficial effects on the adult pulmonary circulation. Indeed, iNO is the therapy of choice in humans presenting neonatal pulmonary hypertension. Long-term effects of neonatal iNO therapy on adult pulmonary circulation have not yet been investigated. Pregnant mice were placed in hypoxia (13% O2) with simultaneous administration of iNO 5 days before delivery until 5 days after birth. Pups were then raised in normoxia until adulthood. Perinatal iNO administration completely restored acetylcholine-induced relaxation, as well as endothelial nitric oxide synthase protein content, in isolated pulmonary arteries of adult mice born in hypoxia. Right ventricular hypertrophy observed in old mice born in hypoxia compared to controls was also prevented by perinatal iNO treatment. Therefore, simultaneous administration of iNO during perinatal hypoxic exposure seems able to prevent adverse effects of perinatal hypoxia on the adult pulmonary circulation.
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/11/2014 9:22
Dernière modification de la notice
20/08/2019 12:52
Données d'usage