Sentinel node mapping in papillary thyroid carcinoma using combined radiotracer and blue dye methods.
Détails
ID Serval
serval:BIB_1B7FCF1A3DAD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sentinel node mapping in papillary thyroid carcinoma using combined radiotracer and blue dye methods.
Périodique
Endokrynologia Polska
ISSN
2299-8306 (Electronic)
ISSN-L
0423-104X
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
65
Numéro
4
Pages
281-286
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
In the current study, we evaluated the accuracy of sentinel node mapping in thyroid cancer patients using both radiotracer and blue dye.
30 patients with a diagnosis of papillary thyroid carcinoma (PTC) were included in the study; 2-3 hours before surgery, 0.5 mCi 99m-Tc-Antimony Sulfide Colloid was injected intra-tumourally. 15 minutes post-injection, lymphoscintigraphy images of the neck were obtained. Immediately after anaesthesia induction, 0.5 mL patent blue V was also injected in the same fashion. Sentinel lymph nodes were detected intraoperatively using gamma probe and blue dye. Total thyroidectomy was performed for all patients with dissection of central neck lymph nodes as well as sampling of the lateral neck lymph nodes.
At least one sentinel node could be identified during surgery in 19 patients (63.3%). The median number of sentinel nodes per patient was 1. Sentinel nodes in 12 patients were pathologically involved. No false negative case was noted. Upstaging occurred in six patients (20%).
Sentinel node mapping in papillary thyroid carcinoma is a feasible technique with high accuracy for the detection of lymph node involvement. This technique can guide surgeons to perform central lymph node dissection only in patients with pathologically involved sentinel nodes. Although SLN detection in the lateral neck lymph nodes increases the extension of lymphadenectomy, SLN mapping can result in upstaging in older patients (> 45 years of age) or treatment plan change in younger patients (< 45 years of age) by the detection of lateral lymph node involvement.
30 patients with a diagnosis of papillary thyroid carcinoma (PTC) were included in the study; 2-3 hours before surgery, 0.5 mCi 99m-Tc-Antimony Sulfide Colloid was injected intra-tumourally. 15 minutes post-injection, lymphoscintigraphy images of the neck were obtained. Immediately after anaesthesia induction, 0.5 mL patent blue V was also injected in the same fashion. Sentinel lymph nodes were detected intraoperatively using gamma probe and blue dye. Total thyroidectomy was performed for all patients with dissection of central neck lymph nodes as well as sampling of the lateral neck lymph nodes.
At least one sentinel node could be identified during surgery in 19 patients (63.3%). The median number of sentinel nodes per patient was 1. Sentinel nodes in 12 patients were pathologically involved. No false negative case was noted. Upstaging occurred in six patients (20%).
Sentinel node mapping in papillary thyroid carcinoma is a feasible technique with high accuracy for the detection of lymph node involvement. This technique can guide surgeons to perform central lymph node dissection only in patients with pathologically involved sentinel nodes. Although SLN detection in the lateral neck lymph nodes increases the extension of lymphadenectomy, SLN mapping can result in upstaging in older patients (> 45 years of age) or treatment plan change in younger patients (< 45 years of age) by the detection of lateral lymph node involvement.
Mots-clé
Adult, Carcinoma, Papillary/diagnostic imaging, Carcinoma, Papillary/pathology, Carcinoma, Papillary/surgery, Female, Humans, Lymph Nodes/diagnostic imaging, Lymphatic Metastasis/diagnostic imaging, Male, Middle Aged, Neck Dissection, Neoplasm Staging, Radionuclide Imaging, Sentinel Lymph Node Biopsy, Thyroid Neoplasms/diagnostic imaging, Thyroid Neoplasms/pathology, Thyroid Neoplasms/surgery
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/08/2017 18:23
Dernière modification de la notice
20/08/2019 13:52