Muscular counterpulsation: preliminary results of a non-invasive alternative to intra-aortic balloon pump

Détails

Ressource 1Télécharger: serval:BIB_1B61ECEFA8B4.P001 (246.09 [Ko])
Etat: Public
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ID Serval
serval:BIB_1B61ECEFA8B4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Muscular counterpulsation: preliminary results of a non-invasive alternative to intra-aortic balloon pump
Périodique
European Journal of Cardio-Thoracic Surgery
Auteur(s)
Tozzi  P., Corno  A. F., Lapanashvili  L. V., Von Segesser  L. K.
ISSN
1010-7940 (Print)
Statut éditorial
Publié
Date de publication
10/2004
Volume
26
Numéro
4
Pages
726-9
Notes
Comparative Study
Evaluation Studies
Journal Article --- Old month value: Oct
Résumé
OBJECTIVES: IABP is the most widely used form of temporary cardiac assist and its benefits are well established. We designed an animal study to evaluate a device based on muscular counterpulsation (MCP) that should reproduce the same hemodynamic effects as IABP in a completely non-invasive way. METHODS: Six calves, 60+/-4 kg, divided into 2 groups, in general anaesthesia, equipped with EKG, Swan-Ganz, pressure probe in the femoral artery and flow probe in the left carotid artery, received either IABP through right femoral artery, or muscle counterpulsation (MCP). MCP consists of electrically induced skeletal muscle contraction during early diastole, triggered by EKG and microprocessor controlled by a portable device. For each animal the following parameters were also considered: mean aortic pressure (mAoP), CO, CI, left ventricular stroke work index (LVSWI), systemic vascular resistance (SVR) and mean femoral artery flow (Faf). We did 3 sets of measurements: baseline (BL), after 20 (M20) and 40 (M40) min of cardiac assistance. These measurements have been repeated after 40 min of rest for 3 times. Results are expressed as mean+/-SD. RESULTS: Baseline values: mAoP, 76.51+/-12 mmHg; mCVP, 11.5+/-3 mmHg; CO, 5+/-1 l/min per m(2); LVSWI, 0.77+/-0.2 KJ/m(2); SVR, 1040+/-15 dyns/cm(-5); Faf, 75.5+/-10 ml/min. IABP group: mAoP, 81.1+/-6 mmHg; mCVP, 1+/-0.1 mmHg; CO, 4.5+/-0.7 l/min per m(2); LVSWI, 0.69+/-0.2 KJ/m(2); SVR, 1424+/-8 dyns/cm(-5); Faf, 64.3+/-3 ml/min. MCP group: mAoP, 60.1+/-7 mmHg; mCVP, 23.6+/-2 mmHg; CO, 4.8+/-0.4 l/min per m(2); LVSWI, 0.69+/-0.2 KJ/m(2); SVR, 608+/-25 dyns/cm(-5); Faf, 92.3+/-12 ml/min. CONCLUSIONS: MCP and IABP had the same effects on CO and LVSWI. Moreover, MCP reduced SVR and increased the peripheral circulation without requiring any vascular access nor anticoagulation therapy.
Mots-clé
Animals Cardiac Output Cattle Counterpulsation/instrumentation/*methods Electric Stimulation/methods Hemodynamic Processes *Intra-Aortic Balloon Pumping Models, Animal Vascular Resistance Ventricular Function, Left
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 9:42
Dernière modification de la notice
25/09/2019 6:08
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