Subcortical nuclei volumetry in idiopathic generalized epilepsy
Détails
ID Serval
serval:BIB_1B4AB00D85A2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Subcortical nuclei volumetry in idiopathic generalized epilepsy
Périodique
Epilepsia
ISSN
0013-9580 (Print)
Statut éditorial
Publié
Date de publication
10/2005
Volume
46
Numéro
10
Pages
1642-5
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Résumé
PURPOSE: The exact anatomic and neurophysiologic correlates of idiopathic generalized epilepsy (IGE) in humans are still not well understood, although the thalamus has frequently been invoked as the crucial structure in the generation of primary generalized seizures. The few in vivo magnetic resonance (MR)-based studies in IGE patients suggest an altered cortical/subcortical gray matter ratio, but with no evidence of structural alterations of the thalamus. In this study, we sought to determine the volumes of the other subcortical structures. METHODS: The volumes of the caudate nucleus, putamen, pallidum as well as the thalamus were each determined in both hemispheres in 11 patients with various IGE syndromes, normalized for whole-brain volumes and then compared with 15 age-matched controls. RESULTS: No differences were noted in thalamic volumes, confirming previous reports. However, smaller subcortical volumes were noted in the IGE patients (p < 0.009), mainly due to smaller putamen bilaterally (p < or = 0.015). CONCLUSIONS: It is speculated that the presence of discrete frontal dysfunction, as noted in neuropsychological studies in IGE patients, indirectly supports our results because the putamen projects predominantly to the frontal cortex. Larger studies with more homogeneous patient populations are needed to determine the robustness of these findings and whether they are specific for particular IGE syndromes.
Mots-clé
Adult
Atrophy/pathology
Brain/*pathology
Caudate Nucleus/pathology
Cell Nucleus/*pathology
Cell Size
Epilepsy, Generalized/*pathology/physiopathology
Female
Frontal Lobe/physiopathology
Globus Pallidus/pathology
Humans
Karyometry/methods
Male
Neurons/*pathology
Putamen/pathology
Thalamus/pathology
Pubmed
Web of science
Création de la notice
25/01/2008 12:40
Dernière modification de la notice
20/08/2019 13:52