Restricted expression of the erythroid/brain glucose transporter isoform to perivenous hepatocytes in rats. Modulation by glucose.

Détails

ID Serval
serval:BIB_1B3F4E53476A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Restricted expression of the erythroid/brain glucose transporter isoform to perivenous hepatocytes in rats. Modulation by glucose.
Périodique
Journal of Clinical Investigation
Auteur(s)
Tal M., Schneider D.L., Thorens B., Lodish H.F.
ISSN
0021-9738
Statut éditorial
Publié
Date de publication
09/1990
Peer-reviewed
Oui
Volume
86
Numéro
3
Pages
986-992
Langue
anglais
Résumé
The "erythroid/brain" glucose transporter (GT) isoform is expressed only in a subset of hepatocytes, those forming the first row around the terminal hepatic venules, while the "liver" GT is expressed in all hepatocytes. After 3 d of starvation, a three- to fourfold elevation of expression of the erythroid/brain GT mRNA and protein is detected in the liver as a whole; this correlates with the expression of this GT in more hepatocytes, those forming the first three to four rows around the hepatic venules. Starvation-dependent expression of the erythroid/brain GT on the plasma membrane of these additional hepatocytes is lost within 3 h of glucose refeeding; however, by immunoblotting we show that the protein is still present. Its loss from the surface is possibly explained by internalization.
Mots-clé
Animals, Blotting, Northern, Blotting, Western, Cell Membrane, Fluorescent Antibody Technique, Gene Expression, Glucose, Liver, Monosaccharide Transport Proteins, RNA, Messenger, Rats, Rats, Inbred Strains, Starvation, Time Factors, Tissue Distribution
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 13:41
Dernière modification de la notice
20/08/2019 12:52
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