T cell receptor binding kinetics and special role of Valpha in T cell development and activation.

Détails

ID Serval
serval:BIB_1B3908D54B3B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
T cell receptor binding kinetics and special role of Valpha in T cell development and activation.
Périodique
Immunologic Research
Auteur⸱e⸱s
Gascoigne N.R., Alam S.M., Lin C.M., McGuire M.V., Marine S., Niederberger N., Redpath S., Sim B.C., Travers P.J., Yachi P., Zal M.A., Zal T.
ISSN
0257-277X (Print)
ISSN-L
0257-277X
Statut éditorial
Publié
Date de publication
2000
Volume
21
Numéro
2-3
Pages
225-231
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; ReviewPublication Status: ppublish
Résumé
The kinetics of the interaction between T cell receptor (TCR) and major histocompatibility complex (MHC) has an important role in determining thymocyte-positive and -negative selection in the thymus, as well as in T cell activation. The alpha chain of the TCR is the major player in determining how the TCR fits onto the MHC ligand, and thus has a major role in determining whether a T cell develops as class I or class II restricted. In this article, we summarize recent data from our laboratory and others on the role of polymorphism in the Valpha combining site in determining MHC class restriction, and on kinetic parameters in thymocyte selection.
Mots-clé
Animals, Humans, Kinetics, Lymphocyte Activation, Major Histocompatibility Complex/genetics, Major Histocompatibility Complex/immunology, Polymorphism, Genetic, Receptors, Antigen, T-Cell, alpha-beta/genetics, Receptors, Antigen, T-Cell, alpha-beta/immunology, T-Lymphocytes/immunology
Pubmed
Web of science
Création de la notice
13/09/2013 12:48
Dernière modification de la notice
20/08/2019 12:51
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