Level and change in cognitive test scores predict risk of first stroke.
Détails
ID Serval
serval:BIB_1B31185241E4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Level and change in cognitive test scores predict risk of first stroke.
Périodique
Journal of the American Geriatrics Society
ISSN
1532-5415 (Electronic)
ISSN-L
0002-8614
Statut éditorial
Publié
Date de publication
03/2009
Peer-reviewed
Oui
Volume
57
Numéro
3
Pages
499-505
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
To determine whether cognitive test scores and cognitive decline predict incidence of first diagnosed stroke.
Stroke-free Health and Retirement Study participants were followed on average 7.6 years for self- or proxy-reported first stroke (1,483 events). Predictors included baseline performance on a modified Telephone Interview for Cognitive Status (Mental Status) and Word Recall test and decline between baseline and second assessment in either measure. Hazard ratios (HRs) were estimated using Cox proportional hazards models for the whole sample and stratified according to five major cardiovascular risk factors.
National cohort study of noninstitutionalized adults with a mean baseline age of 64+/-9.9.
Health and Retirement Study participants (n=19,699) aged 50 and older.
Word Recall (HR for 1 standard deviation difference=0.92, 95% confidence interval (CI)=0.86-0.97)) and Mental Status (HR=0.89, 95% CI=0.84-0.95) predicted incident stroke. Mental Status predicted stroke risk in those with (HR=0.93, 95%=0.87-0.99) and without (HR=0.81, 95% CI=0.72-.91) one or more vascular risk factors. Word Recall declines predicted a 16% elevation in subsequent stroke risk (95% CI=1.01-1.34). Declines in Mental Status predicted a 37% elevation in stroke risk (95% CI=1.11-1.70).
Cognitive test scores predict future stroke risk, independent of other major vascular risk factors.
Stroke-free Health and Retirement Study participants were followed on average 7.6 years for self- or proxy-reported first stroke (1,483 events). Predictors included baseline performance on a modified Telephone Interview for Cognitive Status (Mental Status) and Word Recall test and decline between baseline and second assessment in either measure. Hazard ratios (HRs) were estimated using Cox proportional hazards models for the whole sample and stratified according to five major cardiovascular risk factors.
National cohort study of noninstitutionalized adults with a mean baseline age of 64+/-9.9.
Health and Retirement Study participants (n=19,699) aged 50 and older.
Word Recall (HR for 1 standard deviation difference=0.92, 95% confidence interval (CI)=0.86-0.97)) and Mental Status (HR=0.89, 95% CI=0.84-0.95) predicted incident stroke. Mental Status predicted stroke risk in those with (HR=0.93, 95%=0.87-0.99) and without (HR=0.81, 95% CI=0.72-.91) one or more vascular risk factors. Word Recall declines predicted a 16% elevation in subsequent stroke risk (95% CI=1.01-1.34). Declines in Mental Status predicted a 37% elevation in stroke risk (95% CI=1.11-1.70).
Cognitive test scores predict future stroke risk, independent of other major vascular risk factors.
Mots-clé
Aged, Aged, 80 and over, Cognition Disorders/diagnosis, Cognition Disorders/epidemiology, Cohort Studies, Dementia, Vascular/diagnosis, Dementia, Vascular/epidemiology, Female, Follow-Up Studies, Humans, Interviews as Topic, Kaplan-Meier Estimate, Male, Mental Status Schedule/statistics & numerical data, Middle Aged, Predictive Value of Tests, Psychometrics/statistics & numerical data, Risk, Stroke/diagnosis, Stroke/epidemiology, United States
Pubmed
Web of science
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Création de la notice
18/10/2021 13:59
Dernière modification de la notice
04/11/2021 6:40
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