125I-labelled human interferons alpha, beta and gamma: comparative receptor-binding data.

Détails

ID Serval
serval:BIB_1AF50EB9A2B5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
125I-labelled human interferons alpha, beta and gamma: comparative receptor-binding data.
Périodique
Journal of General Virology
Auteur⸱e⸱s
Merlin G., Falcoff E., Aguet M.
ISSN
0022-1317 (Print)
ISSN-L
0022-1317
Statut éditorial
Publié
Date de publication
1985
Volume
66
Numéro
5
Pages
1149-1152
Langue
anglais
Résumé
Binding of 125I-labelled human recombinant DNA interferons (IFNs) alpha-2, beta and gamma was compared on various human lymphoid cells and embryonic fibroblasts. While binding constants were within an order of magnitude for all three interferons (10(-10) to 10(-9) M), no competition was observed between IFN-gamma on the one hand and IFN-alpha 2 and IFN-beta on the other. However, consistent with previous reports, IFN-alpha 2 and IFN-beta competed for presumably common receptors. Depending on the cell type, binding sites for IFN-gamma were expressed in different numbers compared to those for IFN-alpha 2 and IFN-beta. These direct comparative binding studies support the hypothesis that the receptor system for IFN-gamma is unrelated to the IFN-alpha/beta system.
Mots-clé
Binding Sites, Binding, Competitive, Cell Line, Fibroblasts, Humans, Interferon Type I/metabolism, Interferon-gamma/metabolism, Lymphocytes, Receptors, Immunologic/metabolism, Receptors, Interferon
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 11:36
Dernière modification de la notice
20/08/2019 12:51
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