Interferon enhances the expression of Fc gamma receptors.

Détails

ID Serval
serval:BIB_1AF377D96812
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Interferon enhances the expression of Fc gamma receptors.
Périodique
Journal of Immunology
Auteur(s)
Fridman W.H., Gresser I., Bandu M.T., Aguet M., Neauport-Sautes C.
ISSN
0022-1767 (Print)
ISSN-L
0022-1767
Statut éditorial
Publié
Date de publication
1980
Volume
124
Numéro
5
Pages
2436-2441
Langue
anglais
Résumé
Murine T2D4 cells derived from a T cell hybrid line were incubated with partially purified or electrophoretically pure mouse interferon and tested for the expression of Fc gamma R as assessed by a) counting the number of cells forming rosettes with IgG-sensitized sheep erythrocytes, and b) incubating the cells with heat-aggregated rabbit IgG and then determining either the number of cells stained with fluorescein conjugated goat anti-rabbit IgG or the extent of labeling by using radioactive iodinated staphylococcus protein A. Although interferon induced a rapid increase in Fc gamma R expression on the Fc gamma R-positive T2D4 cells, it did not induce either Fc gamma R on the Fc gamma R negative BW5147 cells or Fc gamma R on either cell line. Human leukocyte interferon enhanced the expression of Fc gamma R on human Burkitt cells (Daudi) but did not affect the expression of Fc gamma R on mouse cells. We suggest that interferon may influence several effector functions of the immune system by modulating Fc receptor expression.
Mots-clé
Animals, Cell Line, Dose-Response Relationship, Immunologic, Erythrocytes/immunology, Fluorescent Antibody Technique, Humans, Immunoglobulin G, Immunoglobulin Heavy Chains, Immunoglobulin gamma-Chains, Interferons/pharmacology, Kinetics, Leukocytes/immunology, Mice, Rabbits, Receptors, Fc, Rosette Formation, Sheep, Staphylococcal Protein A/metabolism
Pubmed
Web of science
Création de la notice
28/01/2008 11:36
Dernière modification de la notice
20/08/2019 12:51
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