HIV entry inhibitors

Détails

ID Serval
serval:BIB_1AC21802D15B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
HIV entry inhibitors
Périodique
Lancet
Auteur(s)
Este  J. A., Telenti  A.
ISSN
1474-547X (Electronic)
Statut éditorial
Publié
Date de publication
07/2007
Volume
370
Numéro
9581
Pages
81-8
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Jul 7
Résumé
The need for new classes of antiretroviral drugs has become apparent because of increasing concern about the long-term toxic effects of existing drugs, the need to combat HIV-1 variants that are resistant to treatment, and the frequency of treatment change in drug-experienced patients. Currently, most regimens are combinations of inhibitors of two viral enzymes--reverse transcriptase and protease. Nevertheless, several steps in the HIV replication cycle are potential targets for intervention. These steps can be divided into entry steps, in which viral envelope glycoproteins and their receptors are involved, and postentry steps, involving viral accessory gene products and the cellular proteins with which they interact. New treatment options target viral entry into the cell. These treatments include the HIV fusion inhibitor enfuvirtide, and new HIV coreceptor antagonists in advanced stages of clinical development or in different stages of preclinical development. Here, we review the development of new HIV entry inhibitors, their performance in clinical trials, and their possible role in anti-HIV therapy.
Mots-clé
Anti-HIV Agents/classification/*therapeutic use Clinical Trials HIV Envelope Protein gp41/*therapeutic use HIV Fusion Inhibitors/*therapeutic use HIV Infections/*prevention & control HIV-1/*physiology Heterocyclic Compounds/*therapeutic use Humans Peptide Fragments/*therapeutic use Receptors, CCR5/*antagonists & inhibitors Virus Replication/*drug effects
Pubmed
Web of science
Création de la notice
25/01/2008 14:45
Dernière modification de la notice
20/08/2019 12:51
Données d'usage