Age-related normograms of serum antimüllerian hormone levels in a population of infertile women: a multicenter study.

Détails

ID Serval
serval:BIB_1AA57952E347
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Age-related normograms of serum antimüllerian hormone levels in a population of infertile women: a multicenter study.
Périodique
Fertility and Sterility
Auteur⸱e⸱s
Almog B., Shehata F., Suissa S., Holzer H., Shalom-Paz E., La Marca A., Muttukrishna S., Blazar A., Hackett R., Nelson S.M., Cunha-Filho J.S., Eldar-Geva T., Margalioth E.J., Raine-Fenning N., Jayaprakasan K., McIlveen M., Wunder D., Freour T., Nardo L.G., Balasch J., Peñarrubia J., Smeenk J., Gnoth C., Godehardt E., Lee T.H., Lee M.S., Levin I., Gamzu R., Tulandi T.
ISSN
1556-5653 (Electronic)
ISSN-L
0015-0282
Statut éditorial
Publié
Date de publication
2011
Volume
95
Numéro
7
Pages
2359-2363
Langue
anglais
Résumé
Objective: To produce age-related normograms for serum antimullerian hormone (AMH) level in infertile women without polycystic ovaries (non-PCO).Design: Retrospective cohort analysis.Setting: Fifteen academic reproductive centers.Patient(s): A total of 3,871 infertile women.Intervention(s): Blood sampling for AMH level.Main Outcome Measure(s): Serum AMH levels and correlation between age and different percentiles of AMH.Result(s): Age-related normograms for the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentiles of AMH were produced. We found that the curves of AMH by age for the 3rd to 50th percentiles fit the model and appearance of linear relation, whereas the curves of >75th percentiles fit cubic relation. There were significant differences in AMH and FSH levels and in antral follicle count (AFC) among women aged 24-33 years, 34-38 years, and >= 39 years. Multivariate stepwise linear regression analysis of FSH, age, AFC, and the type of AMH kit as predictors of AMH level shows that all variables are independently associated with AMH level, in the following order: AFC, FSH, type of AMH kit, and age.Conclusion(s): Age-related normograms in non-PCO infertile women for the 3rd to 97th percentiles were produced. These normograms could provide a reference guide for the clinician to consult women with infertility. However, future validation with longitudinal data is still needed. (Fertil Steril (R) 2011; 95: 2359-63. (C) 2011 by American Society for Reproductive Medicine.)
Pubmed
Web of science
Création de la notice
08/06/2011 10:42
Dernière modification de la notice
20/08/2019 13:51
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