A statistical study of the steady state technique for measuring regional cerebral blood flow and oxygen utilisation using 15O.

Détails

ID Serval
serval:BIB_1AA45C0F7F35
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A statistical study of the steady state technique for measuring regional cerebral blood flow and oxygen utilisation using 15O.
Périodique
Journal of Computer Assisted Tomography
Auteur⸱e⸱s
Lammertsma A.A., Heather J.D., Jones T., Frackowiak R.S., Lenzi G.L.
ISSN
0363-8715 (Print)
ISSN-L
0363-8715
Statut éditorial
Publié
Date de publication
1982
Volume
6
Numéro
3
Pages
566-573
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Regional cerebral blood flow and oxygen utilisation can be measured using positron emission tomography and the continuous inhalation of 15O-labelled carbon dioxide and molecular oxygen. However, there is concern about the propagation of errors in this technique. This arises from statistical uncertainties, inherent in the transmission and emission scans, being amplified in the steady state model used for calculating the physiological parameters. The magnitude of this effect has been studied using a series of repeat transmission and emission phantom measurements in which pixel count densities equivalent to those seen in the clinical data were recorded. These measurements have been used to determine the final propagated errors that occur in the calculated values of regional cerebral blood flow, oxygen extraction fraction, and oxygen utilisation rate.
Mots-clé
Brain/metabolism, Carbon Dioxide/diagnostic use, Cerebrovascular Circulation, Humans, Models, Structural, Oxygen Consumption, Oxygen Radioisotopes/diagnostic use, Statistics as Topic, Tomography, Emission-Computed
Pubmed
Web of science
Création de la notice
09/10/2011 18:35
Dernière modification de la notice
20/08/2019 12:51
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