Inhibitors of the renin-angiotensin system

Détails

ID Serval
serval:BIB_1A8842B0AD46
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Inhibitors of the renin-angiotensin system
Périodique
Arzneimittel-Forschung
Auteur(s)
Brunner  H. R., Nussberger  J., Waeber  B.
ISSN
0004-4172 (Print)
Statut éditorial
Publié
Date de publication
02/1993
Volume
43
Numéro
2A
Pages
274-8
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Feb
Résumé
Inhibition of the renin-angiotensin system with angiotensin-converting enzyme inhibitors is well established as a treatment modality for hypertension and congestive heart failure. While converting enzyme inhibitors are well tolerated, they still have some side effects, which rightly or wrongly are attributed to the lack of specificity of the target enzyme for the renin-angiotensin cascade. The attempt is therefore made to inhibit the more specific enzyme renin or to block the angiotensin II receptor. While so far renin inhibitors are generally hampered by insufficient oral bioavailability, potent orally active angiotensin II antagonists are currently in clinical development. Both pharmacologic principles, renin inhibition and angiotensin II antagonism, have been shown to actively reduce blood pressure of hypertensive patients. It remains to be seen whether these newer compounds will be able to replace the converting enzyme inhibitors and exhibit even fewer untoward effects.
Mots-clé
Angiotensin II/antagonists & inhibitors Angiotensin-Converting Enzyme Inhibitors/pharmacology Animals Humans Renin/antagonists & inhibitors Renin-Angiotensin System/*drug effects
Pubmed
Web of science
Création de la notice
05/03/2008 16:40
Dernière modification de la notice
20/08/2019 12:51
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