Abrupt decrease in serum testosterone levels after an oral glucose load in men: implications for screening for hypogonadism.

Détails

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Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_1A470ECD303D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Abrupt decrease in serum testosterone levels after an oral glucose load in men: implications for screening for hypogonadism.
Périodique
Clinical Endocrinology
Auteur(s)
Caronia L.M., Dwyer A.A., Hayden D., Amati F., Pitteloud N., Hayes F.J.
ISSN
1365-2265 (Electronic)
ISSN-L
0300-0664
Statut éditorial
Publié
Date de publication
2013
Volume
78
Numéro
2
Pages
291-296
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
OBJECTIVE: This study examines the physiological impact of a glucose load on serum testosterone (T) levels in men with varying glucose tolerance (GT).
DESIGN: Cross-sectional study.
PATIENTS AND METHODS: 74 men (19-74 years, mean 51·4 ± 1·4 years) underwent a standard 75-g oral glucose tolerance test with blood sampling at 0, 30, 60, 90 and 120 min. Fasting serum glucose, insulin, total T (and calculated free T), LH, SHBG, leptin and cortisol were measured.
RESULTS: 57% of the men had normal GT, 30% had impaired GT and 13% had newly diagnosed type 2 diabetes. Glucose ingestion was associated with a 25% decrease in mean T levels (delta = -4·2 ± 0·3 nm, P < 0·0001). T levels remained suppressed at 120 min compared with baseline (13·7 ± 0·6 vs 16·5 ± 0·7 nm, P < 0·0001) and did not differ across GT or BMI. Of the 66 men with normal T levels at baseline, 10 (15%) had levels that decreased to the hypogonadal range (<9·7 nm) at one or more time points. SHBG, LH and cortisol levels were unchanged. Leptin levels decreased from baseline at all time points (P < 0·0001).
CONCLUSIONS: Glucose ingestion induces a significant reduction in total and free T levels in men, which is similar across the spectrum of glucose tolerance. This decrease in T appears to be because of a direct testicular defect, but the absence of compensatory changes in LH suggests an additional central component. Men found to have low nonfasting T levels should be re-evaluated in the fasting state.
Pubmed
Web of science
Open Access
Oui
Financement(s)
Fonds national suisse / Carrières / PZ00P3-126339
Création de la notice
19/09/2012 18:54
Dernière modification de la notice
20/01/2020 7:20
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