Angiogenesis and the tumor vasculature as antitumor immune modulators: the role of vascular endothelial growth factor and endothelin.

Détails

ID Serval
serval:BIB_1A2730F40FE1
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Angiogenesis and the tumor vasculature as antitumor immune modulators: the role of vascular endothelial growth factor and endothelin.
Périodique
Current Topics In Microbiology and Immunology
Auteur⸱e⸱s
Kandalaft L.E., Motz G.T., Busch J., Coukos G.
ISSN
0070-217X (Print)
ISSN-L
0070-217X
Statut éditorial
Publié
Date de publication
2011
Volume
344
Pages
129-148
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; ReviewPublication Status: ppublish
Résumé
Cancer immunotherapies have yielded promising results in recent years, but new approaches must be utilized if more patients are to experience the benefits of these therapies. Angiogenesis and the tumor endothelium confer unique immune privilege to a growing tumor, with significant effects on diverse immunological processes such as hematopoietic cell maturation, antigen presentation, effector T cell differentiation, cytokine production, adhesion, and T cell homing and extravasation. Here, we review the role of angiogenesis and the tumor endothelium on regulation of the antitumor immune response. We place particular emphasis on the role of vascular endothelial growth factor (VEGF) in the suppression of numerous immunological processes that control tumor progression. Further, we describe the unique crosstalk between the VEGF and endothelin systems, and how their interactions may shape the antitumor immune response. These insights establish new targets for combinatorial approaches to modify existing cancer immunotherapies.
Mots-clé
Animals, Dendritic Cells/physiology, Endothelins/physiology, Humans, Mice, Neoplasms/blood supply, Neoplasms/immunology, Neovascularization, Pathologic/immunology, T-Lymphocytes/immunology, Tumor Escape, Vascular Endothelial Growth Factor A/physiology
Pubmed
Web of science
Création de la notice
14/10/2014 12:43
Dernière modification de la notice
20/08/2019 13:51
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