Anti-Aging Strategies Based on Cellular Reprogramming.

Détails

ID Serval
serval:BIB_19E74B6BB2F9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Anti-Aging Strategies Based on Cellular Reprogramming.
Périodique
Trends in molecular medicine
Auteur(s)
Ocampo A., Reddy P., Belmonte JCI
ISSN
1471-499X (Electronic)
ISSN-L
1471-4914
Statut éditorial
Publié
Date de publication
08/2016
Peer-reviewed
Oui
Volume
22
Numéro
8
Pages
725-738
Langue
anglais
Notes
Publication types: Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Aging can be defined as the progressive decline in the ability of a cell or organism to resist stress and disease. Recent advances in cellular reprogramming technologies have enabled detailed analyses of the aging process, often involving cell types derived from aged individuals, or patients with premature aging syndromes. In this review we discuss how cellular reprogramming allows the recapitulation of aging in a dish, describing novel experimental approaches to investigate the aging process. Finally, we explore the role of epigenetic dysregulation as a driver of aging, discussing how epigenetic reprogramming may be harnessed to ameliorate aging hallmarks, both in vitro and in vivo. A better understanding of the reprogramming process may indeed assist the development of novel therapeutic strategies to extend a healthy lifespan.
Mots-clé
Aging, Aging, Premature/genetics, Aging, Premature/pathology, Aging, Premature/therapy, Animals, Cellular Reprogramming, Cellular Senescence, Epigenesis, Genetic, Humans, Induced Pluripotent Stem Cells/cytology, Induced Pluripotent Stem Cells/metabolism, Induced Pluripotent Stem Cells/pathology, Regenerative Medicine, aging, epigenetics, rejuvenation, reprogramming
Pubmed
Web of science
Création de la notice
14/08/2018 10:30
Dernière modification de la notice
20/08/2019 13:51
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