Sustained Attention and Interference Control Among 7-Year-Old Children With a Familial High Risk of Schizophrenia or Bipolar Disorder-A Nationwide Observational Cohort Study.

Détails

ID Serval
serval:BIB_19CF25A79C49
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sustained Attention and Interference Control Among 7-Year-Old Children With a Familial High Risk of Schizophrenia or Bipolar Disorder-A Nationwide Observational Cohort Study.
Périodique
Biological psychiatry. Cognitive neuroscience and neuroimaging
Auteur(s)
Burton B.K., Vangkilde S., Petersen A., Skovgaard L.T., Jepsen J.R., Hemager N., Christiani C.J., Spang K.S., Ellersgaard D., Greve A., Gantriis D., Eichele H., Mors O., Nordentoft M., Thorup AAE, Plessen K.J.
ISSN
2451-9030 (Electronic)
ISSN-L
2451-9022
Statut éditorial
Publié
Date de publication
08/2018
Peer-reviewed
Oui
Volume
3
Numéro
8
Pages
704-712
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Given the partially shared genetic liability between schizophrenia and bipolar disorder, we aimed to assess whether 7-year-old children with a familial high risk of schizophrenia or bipolar disorder display specific deficits of sustained attention and interference control compared with each other and with control children.
An observational cohort was identified through Danish registries and consisted of 522 children 7 years of age with no, one, or two parents with a diagnosis of schizophrenia or bipolar disorder. Control subjects were matched based on age, sex, and municipality. Sustained attention and interference control were assessed using Conners' Continuous Performance Test II and a modified Eriksen flanker task. Assessors were blinded to group membership of participants. The effect of higher genetic loading was not considered in the statistical models owing to low numbers.
At 7 years of age, children with a familial high risk of schizophrenia displayed deficits of sustained attention and subtle deficits in interference control compared with control children and children with a familial high risk of bipolar disorder. Children with a familial high risk of bipolar disorder displayed similar abilities of sustained attention and interference control as control children except in terms of a lower accuracy.
Our findings suggest distinct neurodevelopmental characteristics in middle childhood of sustained attention and interference control for children of parents with schizophrenia or bipolar disorder.
Mots-clé
Attention/physiology, Bipolar Disorder/complications, Bipolar Disorder/physiopathology, Child, Cognitive Dysfunction/etiology, Cognitive Dysfunction/physiopathology, Cohort Studies, Denmark, Executive Function/physiology, Female, Genetic Predisposition to Disease, Humans, Male, Psychomotor Performance/physiology, Registries, Risk, Schizophrenia/complications, Schizophrenia/physiopathology, Attention, Bipolar disorder, Endophenotypes, First-degree relatives, Interference control, Schizophrenia
Pubmed
Création de la notice
14/08/2018 11:50
Dernière modification de la notice
18/09/2019 6:10
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