A positron emission tomography study of essential tremor: evidence for overactivity of cerebellar connections.

Détails

ID Serval
serval:BIB_19BDBD00BEF8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A positron emission tomography study of essential tremor: evidence for overactivity of cerebellar connections.
Périodique
Annals of Neurology
Auteur(s)
Jenkins I.H., Bain P.G., Colebatch J.G., Thompson P.D., Findley L.J., Frackowiak R.S., Marsden C.D., Brooks D.J.
ISSN
0364-5134 (Print)
ISSN-L
0364-5134
Statut éditorial
Publié
Date de publication
1993
Volume
34
Numéro
1
Pages
82-90
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
The origin of essential tremor is unknown. Animal models have suggested that the inferior olivary nucleus may act as a tremor generator. We used positron emission tomography to study changes in regional cerebral blood flow associated with involuntary postural tremor and passive wrist oscillation in patients with essential tremor. Activation due to voluntary wrist oscillation and arm extension without tremor was studied in normal control subjects. The essential tremor group had bilaterally increased cerebellar blood flow at rest (without tremor) compared with the control group. Involuntary postural tremor was associated with further bilateral cerebellar activation, and also contralateral striatal, thalamic, and sensorimotor cortex activation. Voluntary wrist oscillation, maintained arm extension without tremor, and passive wrist oscillation were all associated with significant ipsilateral rather than bilateral cerebellar activation. We conclude that essential tremor is associated with increased bilateral cerebellar activity both at rest and during tremor.
Mots-clé
Adult, Aged, Aged, 80 and over, Analysis of Variance, Brain/radionuclide imaging, Cerebellum/radionuclide imaging, Female, Humans, Male, Middle Aged, Tomography, Emission-Computed, Tremor/radionuclide imaging
Pubmed
Web of science
Création de la notice
22/09/2011 19:21
Dernière modification de la notice
20/08/2019 12:50
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