Noninvasive Doppler-derived myocardial performance index in rats with myocardial infarction: validation and correlation by conductance catheter.

Détails

ID Serval
serval:BIB_19A7BD4FCE5E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Noninvasive Doppler-derived myocardial performance index in rats with myocardial infarction: validation and correlation by conductance catheter.
Périodique
American Journal of Physiology. Heart and Circulatory Physiology
Auteur(s)
Jegger D., Jeanrenaud X., Nasratullah M., Chassot P.G., Mallik A., Tevaearai H., von Segesser L.K., Segers P., Stergiopulos N.
ISSN
0363-6135
Statut éditorial
Publié
Date de publication
04/2006
Peer-reviewed
Oui
Volume
290
Numéro
4
Pages
H1540-1548
Langue
anglais
Notes
Publication types: Evaluation Studies ; Journal Article
Résumé
The rodent model of myocardial infarction (MI) is extensively used in heart failure studies. However, long-term follow-up of echocardiographic left ventricular (LV) function parameters such as the myocardial performance index (MPI) and its ratio with the fractional shortening (LVFS/MPI) has not been validated in conjunction with invasive indexes, such as those derived from the conductance catheter (CC). Sprague-Dawley rats with left anterior descending coronary artery ligation (MI group, n = 9) were compared with a sham-operated control group (n = 10) without MI. Transthoracic echocardiography (TTE) was performed every 2 wk over an 8-wk period, after which classic TTE parameters, especially MPI and LVFS/MPI, were compared with invasive indexes obtained by using a CC. Serial TTE data showed significant alterations in the majority of the noninvasive functional and structural parameters (classic and novel) studied in the presence of MI. Both MPI and LVFS/MPI significantly (P < 0.05 for all reported values) correlated with body weight (r = -0.58 and 0.76 for MPI and LVFS/MPI, respectively), preload recruitable stroke work (r = -0.61 and 0.63), LV end-diastolic pressure (LVEDP) (r = 0.82 and -0.80), end-diastolic volume (r = 0.61 and -0.58), and end-systolic volume (r = 0.46 and -0.48). Forward stepwise linear regression analysis revealed that, of all variables tested, LVEDP was the only independent determinant of MPI (r = 0.84) and LVFS/MPI (r = 0.83). We conclude that MPI and LVFS/MPI correlate strongly and better than the classic noninvasive TTE parameters with established, invasively assessed indexes of contractility, preload, and volumetry. These findings support the use of these two new noninvasive indexes for long-term analysis of the post-MI LV remodeling.
Mots-clé
Animals, Disease Models, Animal, Echocardiography, Doppler, Color/methods, Heart Catheterization, Heart Function Tests/methods, Image Interpretation, Computer-Assisted/methods, Male, Myocardial Infarction/complications, Myocardial Infarction/ultrasonography, Rats, Rats, Sprague-Dawley, Reproducibility of Results, Sensitivity and Specificity, Severity of Illness Index, Statistics as Topic, Ventricular Dysfunction, Left/etiology, Ventricular Dysfunction, Left/ultrasonography
Pubmed
Web of science
Création de la notice
28/01/2008 11:01
Dernière modification de la notice
20/08/2019 13:50
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