Evaluation of inner retinal function assessed with a novel handheld instrument (RETeval) using flicker electroretinography after anti-VEGF treatment in patients with diabetic macular oedem

Détails

ID Serval
serval:BIB_1974653DC0F4
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Poster: résume de manière illustrée et sur une page unique les résultats d'un projet de recherche. Les résumés de poster doivent être entrés sous "Abstract" et non "Poster".
Collection
Publications
Institution
Titre
Evaluation of inner retinal function assessed with a novel handheld instrument (RETeval) using flicker electroretinography after anti-VEGF treatment in patients with diabetic macular oedem
Titre de la conférence
Congrès annuel Société Suisse d’ophtalmologie. SSO 2019 Interlaken
Auteur(s)
Abdulghafor Mouna
Contributeur(s)
Konstantinidis Lazaros
Organisation
SSO
Adresse
Congress Centre Kursaal
Strandbadstrasse 44
3800 Interlaken
Statut éditorial
Publié
Date de publication
30/08/2019
Pages
3888
Langue
anglais
Résumé
Electroretinographic studies have suggested that anti-VEGF treatment apart from its positive impact on the diabetic macular oedema may have a positive impact on the entire peripheral retinal function.
A flicker ERG recording system has recently been developed (RETeval™ LKC Technologies, Gaithersburg, MD) that makes possible to record ERGs more rapidly and less invasively than the conventional ERG systems.
We compared the amplitudes and implicit times of the flicker electroretinograms measured by the RETeval device before and after treatment with intravitreal anti-VEGF injections in eyes with diabetic macular oedema.
Methods
Prospective pilot study of 25 eyes of 23 patients with type II diabetes treated for macular oedema by intravitreal ranibizumab injections in Jules Gonin University Eye Hospital in Lausanne, Switzerland. Flicker ERGs were recorded with the novel RETevalTM system before treatment and 1 month after the 3rd injection.
Results
The mean implicit time of the flicker ERGs recorded at baseline by theRETeval system was 31.5 msec (SD: 0.7, msec). On the last follow-up examination one month after the last intravitreal injection, the implicit times of the flicker ERGs on the treated eye recorded with the RETevalTM system were significantly shortened to a mean 28 msec (SD:0.6msec) (p< 0.05; paired t-test)
Conclusion
In the present study the flicker ERGs were significantly shortened after intravitreal injections of ranibizumab for diabetic macular oedema that may indicate a functional improvement of the entire retina. The RETeval devise offers a novel, quick and easily accessible method of objective electroretinographic measurements though its clinical significance warrants further studies.
Mots-clé
Retina Vitreous
Création de la notice
04/09/2019 12:17
Dernière modification de la notice
05/09/2019 6:26
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