Rôles des aquaporines dans le cerveau [Roles of aquaporins in the brain]

Détails

ID Serval
serval:BIB_19727622A7E5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Rôles des aquaporines dans le cerveau [Roles of aquaporins in the brain]
Périodique
Médecine Sciences
Auteur(s)
Guérin C.F., Regli L., Badaut J.
ISSN
0767-0974
Statut éditorial
Publié
Date de publication
09/2005
Peer-reviewed
Oui
Volume
21
Numéro
8-9
Pages
747-752
Langue
français
Notes
Publication types: English Abstract ; Journal Article
Résumé
It is now over 10 years ago that aquaporin 1 (AQP1) was discovered and cloned from the red blood cells, and in 2003 the Nobel price in Chemistry was awarded to Pr. Peter Agre for his work on AQPs, highlighting the importance of these proteins in life sciences. AQPs are water channels. To date this protein family is composed of 11 sub-types in mammalians. Three main AQPs described in the mammalian brain are AQP1, AQP4 and AQP9. Several recent studies have shown that these channels are implicated in numerous physiological functions. AQP1 has a role in cerebrospinal fluid formation, whereas AQP4 is involved in water homeostasis and extracellular osmotic pressure in brain parenchyma. AQP4 seems also to have an important function in oedema formation after brain trauma or brain ischemia. AQP9 is implicated in brain energy metabolism. The level of expression of each AQP is highly regulated. After a trauma or an ischemia perturbation of the central nervous system, the level of expression of each AQP is differentially modified, resulting in facilitating oedema formation. At present, the exact role of each AQP is not yet determined. A better understanding of the mechanisms of AQP regulation should permit the development of new pharmacological strategies to prevent oedema formation. AQP9 has been recently specifically detected in the catecholaminergic neurons of the brain. This new result strengthens the hypothesis that the AQPs are not only water channels, but that some AQPs may play a role in energy metabolism as metabolite channels.
Mots-clé
Aquaporins/chemistry, Aquaporins/physiology, Brain/physiology, Cell Membrane/physiology, Erythrocytes/physiology, Humans, Models, Molecular, Protein Conformation
Pubmed
Web of science
Création de la notice
29/01/2008 14:22
Dernière modification de la notice
20/08/2019 12:50
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