Effects of corticosterone pellets on baseline and stress-induced corticosterone and corticosteroid-binding-globulin.

Détails

Ressource 1Télécharger: BIB_1969252BFD27.P001.pdf (271.19 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_1969252BFD27
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effects of corticosterone pellets on baseline and stress-induced corticosterone and corticosteroid-binding-globulin.
Périodique
General and Comparative Endocrinology
Auteur(s)
Müller C., Almasi B., Roulin A., Breuner C.W., Jenni-Eiermann S., Jenni L.
ISSN
1095-6840 (electronic)
0016-6480 (linking)
Statut éditorial
Publié
Date de publication
01/2009
Peer-reviewed
Oui
Volume
160
Numéro
1
Pages
59-66
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Exogenous administration of glucocorticoids is a widely used and efficient tool to investigate the effects of elevated concentrations of these hormones in field studies. Because the effects of corticosterone are dose and duration-dependent, the exact course of plasma corticosterone levels after exogenous administration needs to be known. We tested the performance of self-degradable corticosterone pellets (implanted under the skin) in elevating plasma corticosterone levels. We monitored baseline (sampled within 3min after capture) total corticosterone levels and investigated potential interactions with corticosteroid-binding-globulin (CBG) capacity and the endogenous corticosterone response to handling in Eurasian kestrel Falco tinnunculus and barn owl Tyto alba nestlings. Corticosterone pellets designed for a 7-day-release in rodents elevated circulating baseline total corticosterone during only 2-3 days compared to placebo-nestlings. Highest levels occurred 1-2days after implantation and levels decreased strongly thereafter. CBG capacity was also increased, resulting in a smaller, but still significant, increase in baseline free corticosterone levels. The release of endogenous corticosterone as a response to handling was strong in placebo-nestlings, but absent 2 and 8 days after corticosterone pellet implantation. This indicates a potential shut-down of the hypothalamo-pituitary-adrenal axis after the 2-3 days of elevated baseline corticosterone levels. 20 days after pellet implantation, the endogenous corticosterone response to handling of nestlings implanted with corticosterone pellets attained similar levels as in placebo-nestlings. Self-degradable pellets proved to be an efficient tool to artificially elevate circulating baseline corticosterone especially in field studies, requiring only one intervention. The resulting peak-like elevation of circulating corticosterone, the concomitant elevation of CBG capacity, and the absence of an endogenous corticosterone response to an acute stressor have to be taken into account.
Mots-clé
Animals, Animals, Newborn, Corticosterone/administration &amp, dosage, Corticosterone/blood, Falconiformes, Stress, Physiological/physiology, Strigiformes, Transcortin/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/10/2008 9:42
Dernière modification de la notice
20/08/2019 13:50
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