Impact of obesity on disease activity and disease outcome in inflammatory bowel disease: Results from the Swiss inflammatory bowel disease cohort.

Détails

ID Serval
serval:BIB_1937B810B969
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Impact of obesity on disease activity and disease outcome in inflammatory bowel disease: Results from the Swiss inflammatory bowel disease cohort.
Périodique
United European gastroenterology journal
Auteur⸱e⸱s
Greuter T., Porchet F., Braga-Neto M.B., Rossel J.B., Biedermann L., Schreiner P., Scharl M., Schoepfer A.M., Safroneeva E., Straumann A., Rogler G., Vavricka S.R.
ISSN
2050-6414 (Electronic)
ISSN-L
2050-6406
Statut éditorial
Publié
Date de publication
12/2020
Peer-reviewed
Oui
Volume
8
Numéro
10
Pages
1196-1207
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The purpose of this study was to investigate the impact of obesity on disease activity and disease outcome in patients with inflammatory bowel disease.
The impact of obesity on inflammatory bowel disease disease activity and outcome was retrospectively assessed in 3075 patients enrolled in the prospective nation-wide Swiss inflammatory bowel disease cohort between July 2006 and September 2018. Baseline characteristics, disease activity and disease course in 325 obese inflammatory bowel disease patients (body mass index ≥30 kg/m <sup>2</sup> ) were compared to 1725 normal weight inflammatory bowel disease individuals (body mass index 18.5-24.9).
Among 3075 patients in the prospective Swiss inflammatory bowel disease cohort, 325 patients (10.6%) were obese, namely, 194 Crohn's disease patients, 131 ulcerative colitis, and inflammatory bowel disease-unclassified patients. Disease activity scores were elevated in obese Crohn's disease (Crohn's Disease Activity Index 33 vs 20, p = 0.001), but not ulcerative colitis patients. Obese Crohn's disease, but not ulcerative colitis patients were less likely to be in remission based on a Crohn's Disease Activity Index less than 100 and a calprotectin less than 100 ug/g. In a multivariate regression model, obesity was negatively associated with disease remission in Crohn's disease (odds ratio 0.610, 95% confidence interval 0.402-0.926, p = 0.020), but not ulcerative colitis. Increased soft stool frequency was observed in both obese Crohn's disease and ulcerative colitis patients. Adjusted Cox regression models revealed increased risk of complicated disease course in obese Crohn's disease patients (hazard ratio 1.197, 95% confidence interval 1.046-1.370, p = 0.009). No association between obesity and disease progression, index treatment failure was seen neither in Crohn's disease nor ulcerative colitis.
Obesity is associated with decreased rates of disease remission and increased risk of complicated disease course in Crohn's disease over a six-year follow-up period. No effects were seen on disease progression and index treatment failure neither in Crohn's disease nor ulcerative colitis.
Mots-clé
Adult, Body Mass Index, Colitis, Ulcerative/diagnosis, Colitis, Ulcerative/epidemiology, Crohn Disease/diagnosis, Crohn Disease/epidemiology, Female, Follow-Up Studies, Humans, Male, Obesity/epidemiology, Odds Ratio, Prospective Studies, Retrospective Studies, Risk Factors, Severity of Illness Index, Switzerland/epidemiology, Young Adult, Crohn’s disease, Inflammatory bowel disease, body mass index, disease activity, disease outcome, natural history, obesity, quality of life, ulcerative colitis
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/12/2020 15:56
Dernière modification de la notice
16/04/2024 7:12
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