Prospective, paired crossover comparison of multiple, single-needle plateletpheresis procedures with the Amicus and Trima Accel cell separators.

Détails

ID Serval
serval:BIB_192A3F92B33C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prospective, paired crossover comparison of multiple, single-needle plateletpheresis procedures with the Amicus and Trima Accel cell separators.
Périodique
Transfusion
Auteur(s)
Fontana S., Mordasini L., Keller P., Taleghani B.M.
ISSN
0041-1132 (Print)
ISSN-L
0041-1132
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
46
Numéro
11
Pages
2004-2010
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Randomized Controlled Trial Publication Status: ppublish
Résumé
BACKGROUND: The Baxter Amicus Version 2.51 (A) and the Gambro BCT Trima Accel Version 5.0 (T) cell separators may produce multiple platelet (PLT) concentrates within a single donation.
STUDY DESIGN AND METHODS: The single-needle multiple plateletpheresis procedures of the two devices were compared in a prospective, randomized, paired crossover study in 60 donors. The 120 donations were compared for donor comfort, collection efficiency, residual white blood cell (WBC) count, and (in selected patients) corrected count increment (CCI).
RESULTS: The mean PLT yield and the resultant mean number of units per donation were significantly lower for A (6.06 x 10(11) vs. 7.48 x 10(11) and 2.57 vs. 3.19, respectively, both p < 0.001), in spite of a longer apheresis duration (89 min vs. 79 min; p < 0.001). This resulted in a higher collection rate of T (5.68 x 10(11) PLTs/hr vs. 4.10 x 10(11) PLTs/hr, p < 0.001). Residual WBC count of every unit was fewer than 5 x 10(6), but significantly fewer A-PLT donations contained more than 10(5) WBCs per unit (1 vs. 9, p = 0.008). Although the ACD-A consumption was slightly higher for A (489 mL vs. 469 mL, p = 0.04), a trend to a higher frequency of side effects was found for T (42.4% vs. 23.7%, p = 0.06). The 1-hour CCIs of 33 transfused A-PLT units were comparable with those of 43 T-PLT units (11.8 vs. 13.9, p = 0.480).
CONCLUSIONS: Both cell separators showed safe collections of up to 4 PLT units per donation with adequate CCI. T produced a higher PLT yield despite shorter apheresis duration, but with slightly higher residual WBC counts and a trend to a higher side-effect frequency.
Mots-clé
Blood Donors, Blood Platelets/cytology, Cross-Over Studies, Female, Humans, Leukocyte Count/methods, Male, Needles, Platelet Transfusion/adverse effects, Platelet Transfusion/methods, Plateletpheresis/instrumentation, Plateletpheresis/methods, Prospective Studies
Pubmed
Web of science
Création de la notice
09/11/2014 18:30
Dernière modification de la notice
20/08/2019 13:49
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