Tissue plasminogen activator in psoriasis

Détails

ID Serval
serval:BIB_18FB8F5B6AE5
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Tissue plasminogen activator in psoriasis
Périodique
Journal of Investigative Dermatology
Auteur(s)
Jensen  P. J., Baird  J., Belin  D., Vassalli  J. D., Busso  N., Gubler  P., Lazarus  G. S.
ISSN
0022-202X (Print)
Statut éditorial
Publié
Date de publication
11/1990
Volume
95
Numéro
5
Pages
13S-14S
Notes
Journal Article
Review --- Old month value: Nov
Résumé
Elevated levels of the serine proteinase plasminogen activator are observed in psoriatic lesions. In contrast to normal epidermis, lesional psoriatic epidermis contains primarily tissue type plasminogen activator (tPA) activity and much lower levels of urokinase type plasminogen activator (uPA) activity. Tissue plasminogen activator is also detectable immunocytochemically in lesional psoriatic but not normal epidermis. Similarly, mRNA for tPA is observed in lesional epidermis only. These results suggest that lesional psoriatic epidermis synthesizes enhanced levels of tPA compared to normal. Additional data support the hypothesis that enhanced tPA may be another marker common to psoriatic epidermis, epidermis during wound repair, and keratinocytes in culture. The significance of elevated tPA in psoriatic lesions is presently unclear, but its possible relationship to epidermal proliferation and cutaneous inflammation is under study.
Mots-clé
Epidermis/cytology/metabolism/pathology Humans Immunohistochemistry Psoriasis/*metabolism Tissue Plasminogen Activator/*metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 9:29
Dernière modification de la notice
20/08/2019 13:49
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