Novel function for interleukin-7 in dendritic cell development.

Détails

ID Serval
serval:BIB_18F8987C64BB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Novel function for interleukin-7 in dendritic cell development.
Périodique
Blood
Auteur⸱e⸱s
Vogt T.K., Link A., Perrin J., Finke D., Luther S.A.
ISSN
1528-0020[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
113
Numéro
17
Pages
3961-3968
Langue
anglais
Résumé
Interleukin-7 (IL-7) is crucial for the development of T and B lymphocytes from common lymphoid progenitors (CLPs) and for the maintenance of mature T lymphocytes. Its in vivo role for dendritic cells (DCs) has been poorly defined. Here, we investigated whether IL-7 is important for the development or maintenance of different DC types. Bone marrow-derived DCs expressed the IL-7 receptor (IL-7R) and survived significantly longer in the presence of IL-7. Migratory DCs (migDCs) isolated from lymph nodes also expressed IL-7R. Surprisingly, IL-7R was not required for their maintenance but indirectly for their development. Conventional DCs (cDCs) and plasmacytoid DCs (pDCs) resident in lymph nodes and spleen were IL-7R(-). Using mixed bone marrow chimeras, we observed an intrinsic requirement for IL-7R signals in their development. As the number of CLPs but not myeloid progenitors was reduced in the absence of IL-7 signals, we propose that a large fraction of cDCs and pDCs derives from CLPs and shares not only the lymphoid origin but also the IL-7 requirement with lymphocyte precursors.
Mots-clé
Animals, Bone Marrow Cells/cytology, Bone Marrow Cells/immunology, Cell Differentiation/immunology, Cells, Cultured, Dendritic Cells/cytology, Dendritic Cells/immunology, Gene Expression Regulation/immunology, Interleukin-7/deficiency, Interleukin-7/genetics, Lymphoid Tissue/cytology, Lymphoid Tissue/immunology, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, Interleukin-7/deficiency, Receptors, Interleukin-7/genetics, Signal Transduction/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/04/2009 15:42
Dernière modification de la notice
20/08/2019 12:49
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