Pathophysiology of growth hormone secretion disorders and their impact on bone microstructure as measured by trabecular bone score.

Détails

ID Serval
serval:BIB_18CD2BD19E68
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Pathophysiology of growth hormone secretion disorders and their impact on bone microstructure as measured by trabecular bone score.
Périodique
Physiological research
Auteur⸱e⸱s
Kužma M., Killinger Z., Jackuliak P., Vaňuga P., Hans D., Binkley N., Payer J.
ISSN
1802-9973 (Electronic)
ISSN-L
0862-8408
Statut éditorial
Publié
Date de publication
30/11/2019
Peer-reviewed
Oui
Volume
68
Numéro
Suppl 2
Pages
S121-S129
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
This article is focused on endocrine-mediated osteoporosis caused by growth hormone (GH) disorders; adult GH deficiency and acromegaly. GH and insulin like growth factor-1 (IGF-1) stimulate linear bone growth through complex hormonal interactions and activates epiphyseal prechondrocytes. GH, via receptor activator of nuclear factor-kappaB (RANK), its ligand (RANK-L), and the osteoprotegerin system, stimulates production of osteoprotegerin and its accumulation in bone matrix. Malfunction of this mechanism, could lead to specific bone impairment. However, the primary problem of bone disease in GH secretion disorders is the primary prevention of osteoporotic fractures, so it is important to determine bone quality that better reflects the patient's actual predisposition to fracture. A method estimating bone quality from lumbar spine dual X-ray absorptiometry (DXA) scans is trabecular bone score (TBS). TBS in addition to bone mineral density (BMD) is a promising predictor of the osteoporotic fracture risk in women with postmenopausal osteopenia. In acromegaly TBS better defines risk of fracture because BMD is normal or even increased. TBS helps to monitor the effect of growth hormone therapy. Despite these findings, TBS should not be used alone, but a comprehensive consideration of all fracture risk factors, BMD and bone turnover markers is necessary.
Pubmed
Web of science
Création de la notice
04/01/2020 10:40
Dernière modification de la notice
14/07/2021 5:40
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