Reactions of tannins with human serum proteoglycans

Détails

ID Serval
serval:BIB_1892
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Reactions of tannins with human serum proteoglycans
Périodique
Journal of Applied Toxicology
Auteur⸱e⸱s
Savolainen H.
ISSN
0260-437X
Statut éditorial
Publié
Date de publication
1997
Peer-reviewed
Oui
Volume
17
Numéro
2
Pages
133-135
Langue
anglais
Notes
Publication types: Journal Article - Publication Status: ppublish
Résumé
Incubation of an isolated human serum proteoglycan fraction with a tannic acid or oak tannin fraction caused a dose-dependent decrease in the total glycan content and a special diminution of a major proteoglycan band with molecular weight 112 kDa in samples as analyzed by polyacrylamide electrophoresis and with carbohydrate staining. Tannic acid was more active than oak tannins while the spruce tannin fraction caused almost no effects. The concentration of plant tannin extracts is often expressed as tannic acid equivalents, which may overestimate their biological activity in this model. This cell-free model may act as a versatile tool for studies on macromolemular interactions of plant polyphenols.
Mots-clé
Drug Interactions, Electrophoresis, Humans, Models, Biological, Proteoglycans/blood, Proteoglycans/pharmacology, Tannins/pharmacology
Pubmed
Web of science
Création de la notice
19/11/2007 12:13
Dernière modification de la notice
20/08/2019 12:49
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