IL-1β Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells.

Détails

ID Serval
serval:BIB_187D70475724
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
IL-1β Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells.
Périodique
Journal of immunology
Auteur(s)
Weiss D.I., Ma F., Merleev A.A., Maverakis E., Gilliet M., Balin S.J., Bryson B.D., Ochoa M.T., Pellegrini M., Bloom B.R., Modlin R.L.
ISSN
1550-6606 (Electronic)
ISSN-L
0022-1767
Statut éditorial
Publié
Date de publication
15/08/2019
Peer-reviewed
Oui
Volume
203
Numéro
4
Pages
911-921
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Résumé
Th17 cells play a critical role in the adaptive immune response against extracellular bacteria, and the possible mechanisms by which they can protect against infection are of particular interest. In this study, we describe, to our knowledge, a novel IL-1β dependent pathway for secretion of the antimicrobial peptide IL-26 from human Th17 cells that is independent of and more rapid than classical TCR activation. We find that IL-26 is secreted 3 hours after treating PBMCs with Mycobacterium leprae as compared with 48 hours for IFN-γ and IL-17A. IL-1β was required for microbial ligand induction of IL-26 and was sufficient to stimulate IL-26 release from Th17 cells. Only IL-1RI <sup>+</sup> Th17 cells responded to IL-1β, inducing an NF-κB-regulated transcriptome. Finally, supernatants from IL-1β-treated memory T cells killed Escherichia coli in an IL-26-dependent manner. These results identify a mechanism by which human IL-1RI <sup>+</sup> "antimicrobial Th17 cells" can be rapidly activated by IL-1β as part of the innate immune response to produce IL-26 to kill extracellular bacteria.
Mots-clé
Bacterial Infections/immunology, Humans, Immunity, Innate/immunology, Interleukin-1beta/immunology, Interleukin-1beta/metabolism, Interleukins/immunology, Interleukins/metabolism, Lymphocyte Activation/immunology, Th17 Cells/immunology, Th17 Cells/microbiology
Pubmed
Web of science
Création de la notice
08/07/2019 16:21
Dernière modification de la notice
27/04/2020 5:20
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