Ethnic differences in biological monitoring of several organic solvents. II. A simulation study with a physiologically based pharmacokinetic model.

Détails

ID Serval
serval:BIB_1877
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Ethnic differences in biological monitoring of several organic solvents. II. A simulation study with a physiologically based pharmacokinetic model.
Périodique
International Archives of Occupational and Environmental Health
Auteur(s)
Jang J.Y., Droz P.O.
ISSN
0340-0131
Statut éditorial
Publié
Date de publication
1997
Peer-reviewed
Oui
Volume
70
Numéro
1
Pages
41-50
Langue
anglais
Notes
Publication types: Comparative Study
Résumé
To improve the reliability of biological monitoring and the development of biological limit values, ethnic differences in the biological monitoring of several organic solvents were studied in Orientals and Caucasians. Six Caucasian and six Oriental volunteers were exposed to each organic solvent in an exposure chamber for 6 h at rest. The exposure concentrations were 50 ppm for perchloroethylene, 50 ppm for styrene, and 100 ppm for m-xylene, respectively. Experimental results were compared with simulation results of a physiologically based pharmacokinetic (PB-PK) model. Differences between Orientals and Caucasians under occupational exposure were also estimated by extrapolation. The simulation results obtained for the Caucasian group showed good agreement with the experimental results. However, the Oriental group did not show good agreement when the same metabolic parameters values applied to Caucasians were used in the PB-PK model. By modification of the metabolic parameters it was possible to get a good fit between the model and the results of the Oriental group. The simulation results obtained for occupational exposure also showed differences in biological levels between the two ethnic groups. Implications of these differences between experimental and simulation results are discussed in the context of the application of biological monitoring and in the development of biological limit values.
Mots-clé
Adult, Asian Continental Ancestry Group, Atmosphere Exposure Chambers, Environmental Monitoring, European Continental Ancestry Group, Humans, Male, Reproducibility of Results, Solvents, Styrene, Styrenes, Tetrachloroethylene, Xylenes
Pubmed
Web of science
Création de la notice
19/11/2007 12:12
Dernière modification de la notice
20/08/2019 12:48
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