Intraoperative lymphatic mapping and sentinel node biopsy using hysteroscopy in patients with endometrial cancer.

Détails

ID Serval
serval:BIB_1863C2D68220
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Intraoperative lymphatic mapping and sentinel node biopsy using hysteroscopy in patients with endometrial cancer.
Périodique
Gynecologic Oncology
Auteur(s)
Delaloye J.F., Pampallona S., Chardonnens E., Fiche M., Lehr H.A., De Grandi P., Delaloye A.B.
ISSN
0090-8258
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
106
Numéro
1
Pages
89-93
Langue
anglais
Notes
Publication types: Clinical Trial ; Journal Article - Publication Status: ppublish
Résumé
OBJECTIVE: The purpose of the study was to assess the feasibility of intraoperative sentinel node (SN) detection using injection of patent blue dye and radioactive tracer beneath the tumor of patients with endometrial carcinoma. METHODS: Hysteroscopy was used for injection of 2 ml of patent-V blue, followed by 20-50 MBq technetium-99 m-labelled nanocolloids into the subendometrial layer underlying the tumor of 60 patients with endometrial cancer. Then SN biopsy, pelvic and paraaortic lymphadenectomy, hysterectomy and bilateral salpingo-oophorectomy were carried out through laparotomy or laparoscopy. RESULTS: Sixty patients aged 43 years to 87 years (median age 65 years) were enrolled in this study. Sentinel nodes were identified in 49 of 60 patients (82%). The mean number of SN retrieved was 3.7 per patient (range, 1 to 8). Sixteen patients (33%) had SN in both pelvic and paraaortic areas. No patient had SN only at the paraaortic level. Metastatic disease was found in 9 patients (15%). In 8 of them at least one SN was positive. CONCLUSION: Intraoperative sentinel node detection is feasible in patients with endometrial carcinoma using hysteroscopy for injection of blue dye and technetium-99 m beneath the tumor. This technique may actually enhance the chances of detecting metastatic disease, while reducing the extent of the surgery.
Mots-clé
Adult, Aged, Aged, 80 and over, Endometrial Neoplasms/pathology, Endometrial Neoplasms/radionuclide imaging, Feasibility Studies, Female, Humans, Hysteroscopy/methods, Intraoperative Period, Lymph Nodes/pathology, Lymph Nodes/radionuclide imaging, Lymphatic Metastasis, Middle Aged, Radiopharmaceuticals/diagnostic use, Rosaniline Dyes/diagnostic use, Sentinel Lymph Node Biopsy/methods, Technetium Tc 99m Aggregated Albumin/diagnostic use
Pubmed
Web of science
Création de la notice
25/01/2008 16:42
Dernière modification de la notice
20/08/2019 13:48
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