PET/CT assessment of neuroendocrine tumors of the lung with special emphasis on bronchial carcinoids.

Détails

ID Serval
serval:BIB_1816C7D79914
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
PET/CT assessment of neuroendocrine tumors of the lung with special emphasis on bronchial carcinoids.
Périodique
Tumour biology
Auteur⸱e⸱s
Lococo F., Cesario A., Paci M., Filice A., Versari A., Rapicetta C., Ricchetti T., Sgarbi G., Alifano M., Cavazza A., Treglia G.
ISSN
1423-0380 (Electronic)
ISSN-L
1010-4283
Statut éditorial
Publié
Date de publication
09/2014
Peer-reviewed
Oui
Volume
35
Numéro
9
Pages
8369-8377
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Pulmonary neuroendocrine tumors (pNETs) arise from bronchial mucosal cells known as enterochromaffin cells which are part of the diffuse neuroendocrine system. The pathological spectrum of pNETs ranges from low-/intermediate-grade neoplasms such as bronchial carcinoids (BCs), also known as typical or atypical carcinoids, to high-grade neoplasms as large-cell neuroendocrine carcinoma and small-cell lung cancer. The tumor biology of pNETs still represents a matter of open debate. The distinct features among the different pNETs include not only their pathologic characteristics but also their clinical behavior, epidemiology, treatment, and prognosis. In this sense, a correct pathological identification in the preoperative setting is a key element for planning the best strategy of care in pNETs and especially in BCs. Controversial results have been reported on the diagnostic accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography or positron emission tomography/computed tomography (F-18-FDG PET or PET/CT) in BCs. On the other hand, there is increasing evidence supporting the use of PET with somatostatin analogues (DOTA-TOC, DOTA-NOC, or DOTA-TATE) labeled with gallium-68 (Ga-68) in pNETs. Herein, we review the pertinent literature aiming to better define the current state of art of PET/CT in the detection and histological differentiation of pNETs with special emphasis on BCs.

Mots-clé
Bronchial Neoplasms/diagnosis, Bronchial Neoplasms/diagnostic imaging, Carcinoid Tumor/diagnosis, Carcinoid Tumor/diagnostic imaging, Carcinoid Tumor/mortality, Fluorodeoxyglucose F18, Humans, Lung Neoplasms/diagnosis, Lung Neoplasms/diagnostic imaging, Neuroendocrine Tumors/diagnosis, Neuroendocrine Tumors/diagnostic imaging, Octreotide/analogs & derivatives, Organometallic Compounds, Positron-Emission Tomography/methods, Sensitivity and Specificity, Tomography, X-Ray Computed/methods
Pubmed
Web of science
Création de la notice
20/08/2017 18:16
Dernière modification de la notice
20/08/2019 12:48
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