Genome-wide analysis identifies 12 loci influencing human reproductive behavior.
Détails
ID Serval
serval:BIB_1811EA937E1C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Genome-wide analysis identifies 12 loci influencing human reproductive behavior.
Périodique
Nature genetics
Collaborateur⸱rice⸱s
BIOS Consortium, LifeLines Cohort Study
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Statut éditorial
Publié
Date de publication
12/2016
Peer-reviewed
Oui
Volume
48
Numéro
12
Pages
1462-1472
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.
Pubmed
Création de la notice
29/11/2016 16:49
Dernière modification de la notice
18/01/2021 22:18