GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics.

Détails

Ressource 1Télécharger: BIB_180FDCC647D0.P001.pdf (443.37 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_180FDCC647D0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics.
Périodique
Human Molecular Genetics
Auteur⸱e⸱s
Ledda M., Kutalik Z., Souza Destito M.C., Souza M.M., Cirillo C.A., Zamboni A., Martin N., Morya E., Sameshima K., Beckmann J.S., le Coutre J., Bergmann S., Genick U.K.
ISSN
1460-2083 (Electronic)
ISSN-L
0964-6906
Statut éditorial
Publié
Date de publication
2014
Volume
23
Numéro
1
Pages
259-267
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Human perception of bitterness displays pronounced interindividual variation. This phenotypic variation is mirrored by equally pronounced genetic variation in the family of bitter taste receptor genes. To better understand the effects of common genetic variations on human bitter taste perception, we conducted a genome-wide association study on a discovery panel of 504 subjects and a validation panel of 104 subjects from the general population of São Paulo in Brazil. Correction for general taste-sensitivity allowed us to identify a SNP in the cluster of bitter taste receptors on chr12 (10.88- 11.24 Mb, build 36.1) significantly associated (best SNP: rs2708377, P = 5.31 × 10(-13), r(2) = 8.9%, β = -0.12, s.e. = 0.016) with the perceived bitterness of caffeine. This association overlaps with-but is statistically distinct from-the previously identified SNP rs10772420 influencing the perception of quinine bitterness that falls in the same bitter taste cluster. We replicated this association to quinine perception (P = 4.97 × 10(-37), r(2) = 23.2%, β = 0.25, s.e. = 0.020) and additionally found the effect of this genetic locus to be concentration specific with a strong impact on the perception of low, but no impact on the perception of high concentrations of quinine. Our study, thus, furthers our understanding of the complex genetic architecture of bitter taste perception.
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/01/2014 19:52
Dernière modification de la notice
20/08/2019 13:48
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