Obesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts.
Détails
Télécharger: 33542229_BIB_17EF0CA720D3.pdf (673.89 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_17EF0CA720D3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Obesity and atypical depression symptoms: findings from Mendelian randomization in two European cohorts.
Périodique
Translational psychiatry
ISSN
2158-3188 (Electronic)
ISSN-L
2158-3188
Statut éditorial
Publié
Date de publication
04/02/2021
Peer-reviewed
Oui
Volume
11
Numéro
1
Pages
96
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Studies considering the causal role of body mass index (BMI) for the predisposition of major depressive disorder (MDD) based on a Mendelian Randomization (MR) approach have shown contradictory results. These inconsistent findings may be attributable to the heterogeneity of MDD; in fact, several studies have documented associations between BMI and mainly the atypical subtype of MDD. Using a MR approach, we investigated the potential causal role of obesity in both the atypical subtype and its five specific symptoms assessed according to the Statistical Manual of Mental Disorders (DSM), in two large European cohorts, CoLaus|PsyCoLaus (n = 3350, 1461 cases and 1889 controls) and NESDA|NTR (n = 4139, 1182 cases and 2957 controls). We first tested general obesity measured by BMI and then the body fat distribution measured by waist-to-hip ratio (WHR). Results suggested that BMI is potentially causally related to the symptom increase in appetite, for which inverse variance weighted, simple median and weighted median MR regression estimated slopes were 0.68 (SE = 0.23, p = 0.004), 0.77 (SE = 0.37, p = 0.036), and 1.11 (SE = 0.39, p = 0.004). No causal effect of BMI or WHR was found on the risk of the atypical subtype or for any of the other atypical symptoms. Our findings show that higher obesity is likely causal for the specific symptom of increase in appetite in depressed participants and reiterate the need to study depression at the granular level of its symptoms to further elucidate potential causal relationships and gain additional insight into its biological underpinnings.
Pubmed
Web of science
Open Access
Oui
Financement(s)
Fonds national suisse / 105993
Fonds national suisse / 118308
Fonds national suisse / 122661
Fonds national suisse / 139468
Fonds national suisse / 148401
Fonds national suisse / 177535
Création de la notice
11/02/2021 11:23
Dernière modification de la notice
30/04/2021 6:08