Human liver carboxylesterases: purification of these two enzymes, properties in relation to cocaine and alcohol metabolism, and specificities.
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Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_17382
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Collection
Publications
Institution
Titre
Human liver carboxylesterases: purification of these two enzymes, properties in relation to cocaine and alcohol metabolism, and specificities.
Titre de la conférence
37th Tiaft Trienna Meeting
Adresse
Cracow, Kraków, September 5-9, 1999
ISBN
1230-7483
ISSN-L
1230-7483
Statut éditorial
Publié
Date de publication
2000
Peer-reviewed
Oui
Volume
43
Série
Problems of forensic Sciences
Pages
35-42
Langue
anglais
Résumé
The purpose of this work was: 1) investigation of cocaine metabolism in association with alcohol intake thoroughly. Carboxylesterases specificities with cocaine and cocaethylene metabolites were determined by incubating one of the two purified enzymes with benzoylecgonine, ecgonine methyl ester, ecgonine ethyl ester, norcocaine and norcocaethylene;
2) determination of each enzyme affinity for various xenobiotics. The first step consisted in isolating carboxylesterases 1 and 2 from human liver obtained by autopsy
2) determination of each enzyme affinity for various xenobiotics. The first step consisted in isolating carboxylesterases 1 and 2 from human liver obtained by autopsy
Mots-clé
Cocaine, Ethanol, Cocaethylene, Carboxylesterases
OAI-PMH
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Création de la notice
19/11/2007 13:11
Dernière modification de la notice
10/03/2020 8:08
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