CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats
Détails
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_16A56D6F045F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats
Périodique
Psychopharmacology
ISSN
0033-3158
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
196
Numéro
3
Pages
473-482
Langue
anglais
Notes
SAPHIRID:67379
Résumé
RATIONALE: Previous work suggests a role for stress-related corticotropin-releasing factor (CRF) systems in cocaine dependence. However, the involvement of activation of CRF(1) receptors in rats self-administering cocaine with extended access is unknown. OBJECTIVE: The current study examined whether CRF(1) receptor antagonist administration alters cocaine self-administration in animals given extended access. MATERIALS AND METHODS: Wistar rats (n = 32) acquired cocaine self-administration (0.66 mg/kg per infusion) in 1 h sessions for up to 11 days. Rats then were assigned to receive either daily short (1 h, ShA) or long (6 h, LgA) access to cocaine self-administration (n = 7-9 per group). Following escalation of intake, animals received one of two selective CRF(1) antagonists: antalarmin (6.3-25 mg/kg, i.p.) or N,N-bis(2-methoxyethyl)-3-(4-methoxy-2-methylphenyl)-2,5-dimethyl-pyrazolo[1,5a]pyrimidin-7-amine (MPZP; 3.6-27.5 mg/kg, s.c.). RESULTS: By day 11 of the escalation period, LgA rats increased their cocaine intake, reaching an intake level of 15.1 mg/kg, compared to 11.1 mg/kg in ShA rats, during the first hour of sessions. Antalarmin reduced cocaine self-administration at the highest dose selectively in the LgA group but not the ShA group. MPZP reduced cocaine intake both in LgA and ShA rats. However, MPZP did so at a lower dose in LgA rats than in ShA rats. Within the LgA group, MPZP decreased cocaine intake in the first 10 min (loading phase) as well as in the latter session intake (maintenance phase). CONCLUSION: The data suggest that hypersensitivity of the CRF system occurs with extended access to cocaine self-administration and that this altered CRF system may contribute to the increased motivation to self-administer cocaine that develops during psychostimulant dependence.
Pubmed
Web of science
Création de la notice
11/03/2008 15:07
Dernière modification de la notice
20/08/2019 13:46