Hepatitis-B-Virusmutanten--klinische Bedeutung. [Hepatitis B virus mutants--clinical significance]

Détails

ID Serval
serval:BIB_16A2282BD747
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Hepatitis-B-Virusmutanten--klinische Bedeutung. [Hepatitis B virus mutants--clinical significance]
Périodique
Zeitschrift fur Gastroenterologie
Auteur(s)
Blum  H. E., Moradpour  D., von Weizsacker  F., Wieland  S., Peters  T., Rasenack  J. W.
ISSN
0044-2771 (Print)
Statut éditorial
Publié
Date de publication
05/1997
Volume
35
Numéro
5
Pages
347-55
Notes
English Abstract
Journal Article
Review --- Old month value: May
Résumé
Hepatitis B virus (HBV) mutants have recently been identified in patients with acute or fulminant as well as chronic infections. Naturally occurring mutations have been identified in all viral genes and regulatory elements, most notably in the genes coding for the structural envelope and nucleocapsid proteins. Mutations in the gene coding for the hepatitis B surface antigen (HBsAg) may result in infection or viral persistence despite the presence of antibodies against HBsAg (anti-HBs) ("vaccine escape" or "immune escape"). Mutations in the gene encoding the pre-core/ core protein (pre-core stop codon mutant) result in a loss of hepatitis B e antigen (HBeAg) and seroconversion to antibodies to HBeAg (anti-HBe) with persistence of HBV replication (HBeAg minus mutant). Mutations in the core gene may lead among others to an "immune escape" due to a T cell receptor antagonism. Mutations in the gene coding for the polymerase/reverse transcriptase can be associated with viral persistence or resistance to nucleoside analogues. Thus, HBV mutations may affect the natural course of infection, viral clearance and response to antiviral therapy. Apart from the precore/core stop codon mutations, the exact contribution of specific mutations to diagnosis and therapy of HBV infection as well as patient management in clinical practice remain to be established.
Mots-clé
Antibody Formation/immunology Genes, Viral/*genetics Hepatitis B/immunology/therapy/*virology Hepatitis B Surface Antigens/genetics/immunology Hepatitis B e Antigens/genetics/immunology Hepatitis B virus/*genetics/immunology Hepatitis, Chronic/immunology/therapy/*virology Humans Mutation/*genetics Treatment Outcome Virus Replication/genetics/immunology
Pubmed
Web of science
Création de la notice
25/01/2008 16:05
Dernière modification de la notice
20/08/2019 12:46
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