Group A streptococcal disease in paediatric inpatients: a European perspective.
Détails
ID Serval
serval:BIB_1686AC1E7BC6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Group A streptococcal disease in paediatric inpatients: a European perspective.
Périodique
European journal of pediatrics
Collaborateur⸱rice⸱s
EUCLIDS consortium
Contributeur⸱rice⸱s
Levin M., Coin L., Gormley S., Hamilton S., Herberg J., Hourmat B., Hoggart C., Kaforou M., Sancho-Shimizu V., Wright V., Abdulla A., Agapow P., Bartlett M., Bellos E., Eleftherohorinou H., Galassini R., Inwald D., Mashbat M., Menikou S., Mustafa S., Nadel S., Rahman R., Thakker C., Bokhandi S., Power S., Barham H., Pathan N., Ridout J., White D., Thurston S., Faust S., Patel S., McCorkell J., Davies P., Crate L., Navarra H., Carter S., Ramaiah R., Patel R., Tuffrey C., Gribbin A., McCready S., Peters M., Hardy K., Standing F., O'Neill L., Abelake E., Deep A., Nsirim E., Pollard A., Willis L., Young Z., Royad C., White S., Fortune P.M., Hudnott P., Martinón-Torres F., Salas A., González F.Á., Barral-Arca R., Cebey-López M., Curras-Tuala M.J., García N., Vicente L.G., Gómez-Carballa A., Rial J.G., Beiroa A.G., Grande A.J., Iglesias P.L., Santos AEM, Martinón-Torres F., Martinón-Torres N., Sánchez JMM, Gutiérrez B.M., Pérez B.M., Pacheco P.O., Pardo-Seco J., Pischedda S., Calle I.R., Rodríguez-Tenreiro C., Redondo-Collazo L., Ellacuriaga A.S., Fernández S.S., Del Sol Porto Silva M., Vega A., Trillo L.V., Reyes S.B., León León M.C., Mingorance Á.N., Barrios X.G., Vergara E.O., Torre A.C., Vivanco A., Fernández R., Sánchez F.G., Forte M.S., Rojo P., Contreras J.R., Palacios A., Ibarrondo C.E., Cooke E.F., Navarro M., Álvarez Álvarez C., Lozano M.J., Carreras E., Sanagustín S.B., Neth O., Del Carmen Martínez Padilla M., Tato LMP, Guillén S., Silveira L.F., Moreno D., de Groot R., van Furth AMT, van der Flier M., Boeddha N.P., Driessen GJA, Emonts M., Hazelzet J.A., Kuijpers T.W., Pajkrt D., Sanders EAM, van de Beek D., van der Ende A., Philipsen HLA, Adeel AOA, Breukels M.A., Brinkman DMC, de Korte CCMM, de Vries E., de Waal W.J., Dekkers R., Dings-Lammertink A., Doedens R.A., Donker A.E., Dousma M., Faber T.E., Gerrits GPJM, Gerver JAM, Heidema J., Homan-van der Veen J., Jacobs MAM, Jansen NJG, Kawczynski P., Klucovska K., Kneyber MCJ, Koopman-Keemink Y., Langenhorst V.J., Leusink J., Loza B.F., Merth I.T., Miedema C.J., Neeleman C., Noordzij J.G., Obihara C.C., van Overbeek-van Gils ALT, Poortman G.H., Potgieter S.T., Potjewijd J., Rosias PPR, Sprong T., Ten Tussher G.W., Thio B.J., Tramper-Stranders G.A., van Deuren M., van der Meer H., van Kuppevelt AJM, van Wermeskerken A.M., Verwijs W.A., Wolfs TFW, Schlapbach L.J., Agyeman P., Aebi C., Giannoni E., Stocker M., Posfay-Barbe K.M., Heininger U., Bernhard-Stirnemann S., Niederer-Loher A., Kahlert C., Hasters P., Relly C., Baer W., Berger C., Carrol E.D., Paulus S., Frederick H., Jennings R., Johnston J., Kenwright R., Fink C.G., Pinnock E., Emonts M., Agbeko R., Anderson S., Secka F., Bojang K., Sarr I., Kebbeh N., Sey G., Saidykhan M., Cole F., Thomas G., Antonio M., Zenz W., Klobassa D.S., Binder A., Schweintzger N.A., Sagmeister M., Baumgart H., Baumgartner M., Behrends U., Biebl A., Birnbacher R., Blanke J.G., Boelke C., Breuling K., Brunner J., Buller M., Dahlem P., Dietrich B., Eber E., Elias J., Emhofer J., Etschmaier R., Farr S., Girtler Y., Grigorow I., Heimann K., Ihm U., Jaros Z., Kalhoff H., Kaulfersch W., Kemen C., Klocker N., Köster B., Kohlmaier B., Komini E., Kramer L., Neubert A., Ortner D., Pescollderungg L., Pfurtscheller K., Reiter K., Ristic G., Rödl S., Sellner A., Sonnleitner A., Sperl M., Stelzl W., Till H., Trobisch A., Vierzig A., Vogel U., Weingarten C., Welke S., Wimmer A., Wintergerst U., Wüller D., Zaunschirm A., Ziuraite I., Žukovskaja V., Mikula C., Feierl G., Binder A., Zenz W., Walcher W., Geishofer G., Klobassa D., Martin M., Pfurtscheller K., Reiter K., Rödl S., Zobel G., Zöhrer B., Töpke B., Fucik P., Gabriel M., Penzien J.M., Diab G., Miething R., Deeg K.H., Hammer J., Heininger U., Varnholt V., Schmidt A., Bindl L., Sillaber U., Huemer C., Meier P., Simic-Schleicher G., Markart M., Pfau E., Broede H., Ausserer B., Kalhoff H., Arpe V., Schweitzer-Krantz S., Kasper J.M., Loranth K., Bittrich H.J., Simma B., Klinge J., Fedlmaier M., Weigand N., Herting E., Grube R., Fusch C., Gruber A., Schimmel U., Knaufer-Schiefer S., Lässig W., Hennenberger A., von der Wense A., Tillmann R., Schwarick J., Sitzmann F.C., Streif W., Müller H., Kurnik P., Groneck P., Weiss U., Gröblacher-Roth H., Bensch J., Moser R., Schwarz R., Lenz K., Hofmann T., Göpel W., Schulz D., Berger T., Hauser E., Förster K.M., Peters J., Nicolai T., Kumlien B., Beckmann R., Seitz C., Hüseman D., Schürmann R., Ta V.H., Weikmann E., Evert W., Hautz J., Seidenberg J., Wocko L., Luigs P., Reiter H.L., Quietzach J., König M., Herrmann J., Mitter H., Seidler E., Maak B., Sperl W., Zwiauer K., Meissl M., Koch R., Cremer M., Breuer H.A., Görke W., Nossal R., Pernice W., Brangenberg R., Salzer H.R., Koch H., Schaller G., Paky F., Straßer F., Eitelberger F., Sontheimer D., Lischka A., Kronberger M., Dilch A., Scheibenpflug C., Bruckner R., Mahler K., Runge K., Kunze W., Schermann P.
ISSN
1432-1076 (Electronic)
ISSN-L
0340-6199
Statut éditorial
Publié
Date de publication
02/2023
Peer-reviewed
Oui
Volume
182
Numéro
2
Pages
697-706
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Group A streptococcal (GAS) disease shows increasing incidence worldwide. We characterised children admitted with GAS infection to European hospitals and studied risk factors for severity and disability. This is a prospective, multicentre, cohort study (embedded in EUCLIDS and the Swiss Pediatric Sepsis Study) including 320 children, aged 1 month to 18 years, admitted with GAS infection to 41 hospitals in 6 European countries from 2012 to 2016. Demographic, clinical, microbiological and outcome data were collected. A total of 195 (61%) patients had sepsis. Two hundred thirty-six (74%) patients had GAS detected from a normally sterile site. The most common infection sites were the lower respiratory tract (LRTI) (22%), skin and soft tissue (SSTI) (23%) and bone and joint (19%). Compared to patients not admitted to PICU, patients admitted to PICU more commonly had LRTI (39 vs 8%), infection without a focus (22 vs 8%) and intracranial infection (9 vs 3%); less commonly had SSTI and bone and joint infections (p < 0.001); and were younger (median 40 (IQR 21-83) vs 56 (IQR 36-85) months, p = 0.01). Six PICU patients (2%) died. Sequelae at discharge from hospital were largely limited to patients admitted to PICU (29 vs 3%, p < 0.001; 12% overall) and included neurodisability, amputation, skin grafts, hearing loss and need for surgery. More patients were recruited in winter and spring (p < 0.001).
In an era of observed marked reduction in vaccine-preventable infections, GAS infection requiring hospital admission is still associated with significant severe disease in younger children, and short- and long-term morbidity. Further advances are required in the prevention and early recognition of GAS disease.
• Despite temporal and geographical variability, there is an increase of incidence of infection with group A streptococci. However, data on the epidemiology of group A streptococcal infections in European children is limited.
• In a large, prospective cohort of children with community-acquired bacterial infection requiring hospitalisation in Europe, GAS was the most frequent pathogen, with 12% disability at discharge, and 2% mortality in patients with GAS infection. • In children with GAS sepsis, IVIG was used in only 4.6% of patients and clindamycin in 29% of patients.
In an era of observed marked reduction in vaccine-preventable infections, GAS infection requiring hospital admission is still associated with significant severe disease in younger children, and short- and long-term morbidity. Further advances are required in the prevention and early recognition of GAS disease.
• Despite temporal and geographical variability, there is an increase of incidence of infection with group A streptococci. However, data on the epidemiology of group A streptococcal infections in European children is limited.
• In a large, prospective cohort of children with community-acquired bacterial infection requiring hospitalisation in Europe, GAS was the most frequent pathogen, with 12% disability at discharge, and 2% mortality in patients with GAS infection. • In children with GAS sepsis, IVIG was used in only 4.6% of patients and clindamycin in 29% of patients.
Mots-clé
Child, Humans, Infant, Cohort Studies, Inpatients, Prospective Studies, Streptococcal Infections/diagnosis, Streptococcal Infections/epidemiology, Streptococcal Infections/complications, Sepsis/complications, Community-Acquired Infections/complications, Intensive Care Units, Pediatric, Hospital, Outcome, Streptococcus pyogenes
Pubmed
Web of science
Site de l'éditeur
Open Access
Oui
Création de la notice
28/08/2024 9:22
Dernière modification de la notice
30/10/2024 7:18
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