Bidirectional GABAergic control of action potential firing in newborn hippocampal granule cells.

Détails

ID Serval
serval:BIB_16832D394E31
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Bidirectional GABAergic control of action potential firing in newborn hippocampal granule cells.
Périodique
Nature Neuroscience
Auteur⸱e⸱s
Heigele S., Sultan S., Toni N., Bischofberger J.
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
19
Numéro
2
Pages
263-270
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Newly generated young neurons in the adult hippocampus receive GABAergic synaptic inputs, which are crucial for activity-dependent survival and functional maturation between 1-3 weeks after mitosis. We found synaptically driven action potential (AP) firing in these newborn young cells in adult mice. Although glutamatergic synaptic inputs remained subthreshold, activation of GABAergic synaptic inputs depolarized young neurons and reliably evoked APs. Furthermore, pairing of subthreshold excitatory postsynaptic potentials or somatic current injection with brief bursts of GABAergic inputs revealed efficient GABAergic excitation at conductances of ∼ 1.5 nS, corresponding to the activity of only three or four interneurons. Stronger GABAergic inputs (>4 nS) effectively blocked AP firing via shunting inhibition, which might be important to dynamically control spiking output in both directions. Taken together, GABAergic interneurons differentially recruit newborn young granule cells by supporting either AP generation or shunting inhibition dependent on hippocampal network activity.
Mots-clé
Action Potentials/physiology, Animals, Animals, Newborn, Cytoplasmic Granules, Excitatory Postsynaptic Potentials/physiology, Female, Hippocampus/cytology, Hippocampus/physiology, In Vitro Techniques, Interneurons/physiology, Mice, Mice, Inbred C57BL, Nerve Net/cytology, Nerve Net/physiology, Neurons/physiology, Patch-Clamp Techniques, Pregnancy, Synapses/physiology, gamma-Aminobutyric Acid/physiology
Pubmed
Création de la notice
29/01/2016 8:18
Dernière modification de la notice
20/08/2019 13:46
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