HIV vaccines induce CD8<sup>+</sup> T cells with low antigen receptor sensitivity.
Détails
ID Serval
serval:BIB_16798A6A6CBC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
HIV vaccines induce CD8<sup>+</sup> T cells with low antigen receptor sensitivity.
Périodique
Science
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
15/12/2023
Peer-reviewed
Oui
Volume
382
Numéro
6676
Pages
1270-1276
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Current HIV vaccines designed to stimulate CD8 <sup>+</sup> T cells have failed to induce immunologic control upon infection. The functions of vaccine-induced HIV-specific CD8 <sup>+</sup> T cells were investigated here in detail. Cytotoxic capacity was significantly lower than in HIV controllers and was not a consequence of low frequency or unaccumulated functional cytotoxic proteins. Low cytotoxic capacity was attributable to impaired degranulation in response to the low antigen levels present on HIV-infected targets. The vaccine-induced T cell receptor (TCR) repertoire was polyclonal and transduction of these TCRs conferred the same reduced functions. These results define a mechanism accounting for poor antiviral activity induced by these vaccines and suggest that an effective CD8 <sup>+</sup> T cell response may require a vaccination strategy that drives further TCR clonal selection.
Mots-clé
Humans, CD8-Positive T-Lymphocytes, AIDS Vaccines, Receptors, Antigen, T-Cell, Clone Cells, HIV Infections/prevention & control
Pubmed
Création de la notice
19/12/2023 8:27
Dernière modification de la notice
20/12/2023 7:15