HIV vaccines induce CD8<sup>+</sup> T cells with low antigen receptor sensitivity.

Détails

ID Serval
serval:BIB_16798A6A6CBC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
HIV vaccines induce CD8<sup>+</sup> T cells with low antigen receptor sensitivity.
Périodique
Science
Auteur⸱e⸱s
Migueles S.A., Nettere D.M., Gavil N.V., Wang L.T., Toulmin S.A., Kelly E.P., Ward A.J., Lin S., Thompson S.A., Peterson B.A., Abdeen C.S., Sclafani C.R., Pryal P.F., Leach B.G., Ludwig A.K., Rogan D.C., Przygonska P.A., Cattani A., Imamichi H., Sachs A., Cafri G., Huang N.N., Patamawenu A., Liang C.J., Hallahan C.W., Kambach D.M., Han E.X., Coupet T., Chen J., Moir S.L., Chun T.W., Coates E.E., Ledgerwood J., Schmidt J., Taillandier-Coindard M., Michaux J., Pak H., Bassani-Sternberg M., Frahm N., McElrath M.J., Connors M.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
15/12/2023
Peer-reviewed
Oui
Volume
382
Numéro
6676
Pages
1270-1276
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Current HIV vaccines designed to stimulate CD8 <sup>+</sup> T cells have failed to induce immunologic control upon infection. The functions of vaccine-induced HIV-specific CD8 <sup>+</sup> T cells were investigated here in detail. Cytotoxic capacity was significantly lower than in HIV controllers and was not a consequence of low frequency or unaccumulated functional cytotoxic proteins. Low cytotoxic capacity was attributable to impaired degranulation in response to the low antigen levels present on HIV-infected targets. The vaccine-induced T cell receptor (TCR) repertoire was polyclonal and transduction of these TCRs conferred the same reduced functions. These results define a mechanism accounting for poor antiviral activity induced by these vaccines and suggest that an effective CD8 <sup>+</sup> T cell response may require a vaccination strategy that drives further TCR clonal selection.
Mots-clé
Humans, CD8-Positive T-Lymphocytes, AIDS Vaccines, Receptors, Antigen, T-Cell, Clone Cells, HIV Infections/prevention & control
Pubmed
Création de la notice
19/12/2023 8:27
Dernière modification de la notice
20/12/2023 7:15
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