Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin
Détails
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_1675991FBC85
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin
Périodique
Journal of Cell Biology
ISSN
0021-9525 (Print)
Statut éditorial
Publié
Date de publication
12/2006
Volume
175
Numéro
6
Pages
1005-15
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec 18
Research Support, Non-U.S. Gov't --- Old month value: Dec 18
Résumé
Given their accessibility, multipotent skin-derived cells might be useful for future cell replacement therapies. We describe the isolation of multipotent stem cell-like cells from the adult trunk skin of mice and humans that express the neural crest stem cell markers p75 and Sox10 and display extensive self-renewal capacity in sphere cultures. To determine the origin of these cells, we genetically mapped the fate of neural crest cells in face and trunk skin of mouse. In whisker follicles of the face, many mesenchymal structures are neural crest derived and appear to contain cells with sphere-forming potential. In the trunk skin, however, sphere-forming neural crest-derived cells are restricted to the glial and melanocyte lineages. Thus, self-renewing cells in the adult skin can be obtained from several neural crest derivatives, and these are of distinct nature in face and trunk skin. These findings are relevant for the design of therapeutic strategies because the potential of stem and progenitor cells in vivo likely depends on their nature and origin.
Mots-clé
Adipocytes/cytology/metabolism
Adult
Animals
Cell Differentiation
*Cell Lineage
Cells, Cultured
DNA-Binding Proteins/metabolism
Face
Female
Fluorescent Antibody Technique
Hair Follicle/cytology/physiology
High Mobility Group Proteins/metabolism
Humans
Male
Melanocytes/cytology/physiology
Mice
Mice, Inbred C57BL
Middle Aged
Multipotent Stem Cells/*cytology/physiology
Neural Crest/*cytology/physiology
Neuroglia/cytology/physiology
Skin/*cytology
Transcription Factors/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 9:41
Dernière modification de la notice
20/08/2019 13:46