Mechanisms of skin adherence and invasion by dermatophytes.

Détails

ID Serval
serval:BIB_161FC47222C8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Mechanisms of skin adherence and invasion by dermatophytes.
Périodique
Mycoses
Auteur⸱e⸱s
Baldo A., Monod M., Mathy A., Cambier L., Bagut E.T., Defaweux V., Symoens F., Antoine N., Mignon B.
ISSN
1439-0507 (Electronic)
ISSN-L
0933-7407
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
55
Numéro
3
Pages
218-223
Langue
anglais
Notes
Publication types: JOURNAL ARTICLE
Résumé
Dermatophytes are keratinophilic fungi that can be pathogenic for humans and animals by infecting the stratum corneum, nails, claws or hair. The first infection step consists of adherence of arthroconidia to the stratum corneum. The mechanisms and the kinetics of adherence have been investigated using different in vitro and ex vivo experimental models, most notably showing the role of a secreted serine protease from Microsporum canis in fungal adherence to feline corneocytes. After germination of the arthroconidia, dermatophytes invade keratinised structures that have to be digested into short peptides and amino acids to be assimilated. Although many proteases, including keratinolytic ones, have been characterised, the understanding of dermatophyte invasion mechanisms remains speculative. To date, research on mechanisms of dermatophyte infection focused mainly on both secreted endoproteases and exoproteases, but their precise role in both fungal adherence and skin invasion should be further explored.
Pubmed
Web of science
Création de la notice
12/05/2012 8:38
Dernière modification de la notice
20/08/2019 12:45
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