Neuronal propagation of HSV1 from the oral mucosa to the eye.

Détails

ID Serval
serval:BIB_16193
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Neuronal propagation of HSV1 from the oral mucosa to the eye.
Périodique
Investigative Ophthalmology and Visual Science
Auteur⸱e⸱s
Labetoulle M., Kucera P., Ugolini G., Lafay F., Frau E., Offret H., Flamand A.
ISSN
0146-0404 (Print)
ISSN-L
0146-0404
Statut éditorial
Publié
Date de publication
2000
Volume
41
Numéro
9
Pages
2600-2606
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
PURPOSE: To identify possible neuronal pathways leading to herpetic ocular disease after primary oral infection in mice.
METHODS: The SC16 strain of herpes simplex virus (HSV)-1 (10(6) plaque-forming units) was injected into the mucocutaneous border of the left upper lip. Animals were killed 2 to 10 days postinoculation (DPI). Spread of the virus in neural structures was studied by immunochemistry.
RESULTS: HSV1 first replicated at the site of inoculation and then at the superior cervical ganglion (at 2 DPI). The trigeminal ganglion and the facial nerve fibers were infected by 4 DPI. Infection of the ciliary body and iris occurred at 6 DPI, together with several brain stem nuclei belonging to the autonomic or sensory pathways. Between 8 and 10 DPI, the neural infection gradually cleared up, except for the ipsilateral sympathetic ganglion, and ipsilateral keratitis appeared in some animals.
CONCLUSIONS: The pattern of viral dissemination in this mouse model suggests that infection of iris and ciliary body results from transfer of virus in the superior cervical ganglion from sympathetic neurons innervating the lip to neighboring neurons innervating the anterior uvea. Later, zosteriform spread of virus from the trigeminal system may have contributed to the clinical and histologic findings.
Mots-clé
Animals, Brain Stem/virology, Ciliary Body/innervation, Ciliary Body/virology, Cricetinae, Eye Infections, Viral/pathology, Eye Infections, Viral/virology, Facial Nerve/virology, Female, Herpes Simplex/pathology, Herpes Simplex/virology, Herpesvirus 1, Human/isolation & purification, Herpesvirus 1, Human/physiology, Iris/innervation, Iris/virology, Mice, Mice, Inbred BALB C, Mouth Mucosa/innervation, Mouth Mucosa/pathology, Neural Pathways/virology, Superior Cervical Ganglion/virology, Time Factors, Trigeminal Ganglion/virology, Uveitis, Anterior/pathology, Uveitis, Anterior/virology, Virus Replication/physiology
Pubmed
Web of science
Création de la notice
19/11/2007 12:09
Dernière modification de la notice
20/08/2019 12:45
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