Hepatitis virus-related and ethanol-induced chronic liver disease with or without cryoglobulins--is there a difference concerning clinical or laboratory manifestation?

Détails

ID Serval
serval:BIB_1617C5C2D19D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Hepatitis virus-related and ethanol-induced chronic liver disease with or without cryoglobulins--is there a difference concerning clinical or laboratory manifestation?
Périodique
Infection
Auteur(s)
Breitschwerdt  B., Goeser  T., Tissot  J. D., Trendelenburg  M., Sis-Kluzik  J. M., Andrassy  K.
ISSN
0300-8126 (Print)
Statut éditorial
Publié
Date de publication
1999
Volume
27
Numéro
4-5
Pages
248-51
Notes
Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Résumé
Mixed cryoglobulinemia is frequent in southern Europe and attributed to hepatitis C infection. We analyzed prevalence and clinical symptoms of mixed cryoglobulinemia in our region among patients with chronic hepatitis C (n = 29) and B (n = 7) in comparison to alcoholic liver cirrhosis without evidence of hepatitis virus infection (n = 10). Cryoglobulinemia was found in 13/29 patients with hepatitis C (11 type III, one type I1-III and one type II), 2/7 with hepatitis B (one type II, one type III) and 4/10 with alcoholic liver cirrhosis (one type II, three type III). Patients with moderate active hepatitis had more type II than type III cryoglobulins. Concerning clinical symptoms, only sicca syndrome was more frequent in patients with hepatitis C. Rheumatoid factor (RF) and immune globulin M (IgM) levels were higher in hepatitis C than in the other groups. Renal disease was rare in all but not different between the groups. Mixed cryoglobulinemia in hepatitis C (and B) is most frequently of type III. Patients with hepatitis C had the same prevalence of cryoglobulins as patients with alcoholic liver cirrhosis. Cryoglobulins had no influence on clinical syndromes or organ damage.
Mots-clé
Adolescent Adult Biopsy Child, Preschool Comorbidity Cryoglobulinemia/*diagnosis/epidemiology Cryoglobulins/*analysis Diagnosis, Differential Female Germany/epidemiology Hepatitis B, Chronic/blood/*diagnosis/epidemiology Hepatitis C, Chronic/blood/*diagnosis/epidemiology Humans Incidence Kidney/pathology Liver Cirrhosis, Alcoholic/blood/*diagnosis/epidemiology Male Middle Aged Probability Prognosis Risk Factors Sensitivity and Specificity Statistics, Nonparametric
Pubmed
Web of science
Création de la notice
25/01/2008 16:34
Dernière modification de la notice
20/08/2019 13:45
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