Polyclonal and monoclonal thyroid nodules coexist within human multinodular goiters.

Détails

ID Serval
serval:BIB_161590C1B0F9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Polyclonal and monoclonal thyroid nodules coexist within human multinodular goiters.
Périodique
The Journal of clinical endocrinology and metabolism
Auteur(s)
Kopp P., Kimura E.T., Aeschimann S., Oestreicher M., Tobler A., Fey M.F., Studer H.
ISSN
0021-972X (Print)
ISSN-L
0021-972X
Statut éditorial
Publié
Date de publication
07/1994
Peer-reviewed
Oui
Volume
79
Numéro
1
Pages
134-139
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Although somatic mutations have been identified in a subset of thyroid nodules, the pathogenesis of nodules in multinodular goiters remains unclear. Clonal analysis indicates whether a nodule arises from the polyclonal proliferation of a group of cells or forms a clone from a genetically altered cell. Individual thyroid nodules have been shown to be of polyclonal or monoclonal origin. In this study we examined the clonality of several different nodules in patients with multinodular goiters. Clonality was established using the X-chromosomal probe M27 beta, which detects a multiallelic polymorphism at the locus DXS255 in 90% of females. Twenty-five nodules from 9 multinodular goiters were analyzed; 9 nodules were polyclonal, and 16 were monoclonal. Three goiters contained only polyclonal nodules, whereas 3 contained only monoclonal nodules. Polyclonal and monoclonal nodules coexisted in 3 goiters. In 2 goiters, the monoclonal nodules were shown to derive from different progenitor cells. We conclude that polyclonal and monoclonal nodules may coexist in multinodular goiters and that monoclonal nodules can originate from different cells. The coexistence of polyclonal and monoclonal nodules suggests that different pathogenic mechanisms occur simultaneously or that monoclonal nodules emerge secondarily from a polyclonal population due to a growth advantage from a genetically altered cell.
Mots-clé
Adult, Aged, Blotting, Southern, Clone Cells, DNA Probes, Deoxyribonuclease HpaII, Deoxyribonucleases, Type II Site-Specific, Dosage Compensation, Genetic, Female, Genetic Markers, Goiter, Nodular/genetics, Goiter, Nodular/pathology, Humans, Male, Middle Aged, Polymorphism, Restriction Fragment Length, Stem Cells/pathology
Pubmed
Web of science
Création de la notice
30/12/2020 16:45
Dernière modification de la notice
31/12/2020 7:26
Données d'usage