The development of mother-infant interactions after neonatal amygdala lesions in rhesus monkeys

Détails

ID Serval
serval:BIB_15C2A7A3E62E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The development of mother-infant interactions after neonatal amygdala lesions in rhesus monkeys
Périodique
Journal of Neuroscience
Auteur(s)
Bauman M.D., Lavenex P., Mason W.A., Capitanio J.P., Amaral D.G.
ISSN
1529-2401 (Electronic)
0270-6474 (Print)
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
24
Numéro
3
Pages
711-721
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. Publication Status: ppublish
Résumé
As part of ongoing studies on the neurobiology of socioemotional behavior in the nonhuman primate, we examined the development of mother-infant interactions in 24 macaque monkeys who received either bilateral amygdala or hippocampus ibotenic acid lesions, or a sham surgical procedure at 2 weeks of age. After surgery, the infants were returned to their mothers and reared with daily access to small social groups. Behavioral observations of the infants in dyads (mother-infant pairs alone), tetrads (two mother-infant pairs), and social groups (six mother-infant pairs and one adult male) revealed species-typical mother-infant interactions for all lesion conditions, with the exception of increased physical contact time between the amygdala-lesioned infants and their mothers. Immediately after permanent separation from their mothers at 6 months of age, the infants were tested in a mother preference test that allowed the infants to choose between their mother and another familiar adult female. Unlike control and hippocampus-lesioned infants, the amygdala-lesioned infants did not preferentially seek proximity to their mother, nor did they produce distress vocalizations. Given the normal development of mother-infant interactions observed before weaning, we attribute the behavior of the amygdala-lesioned infants during the preference test to an impaired ability to perceive potential danger (i.e., separation from their mother in a novel environment), rather than to a disruption of the mother-infant relationship. These results are consistent with the view that the amygdala is not essential for fundamental aspects of social behavior but is necessary to evaluate potentially dangerous situations and to coordinate appropriate behavioral responses.
Mots-clé
Age Factors, Amygdala/drug effects, Amygdala/physiology, Animals, Animals, Newborn, Behavior, Animal/physiology, Choice Behavior/physiology, Fear/physiology, Female, Ibotenic Acid/pharmacology, Macaca mulatta/physiology, Macaca mulatta/psychology, Male, Maternal Deprivation, Object Attachment, Recognition (Psychology)/physiology, Social Behavior
Pubmed
Open Access
Oui
Création de la notice
13/10/2014 18:50
Dernière modification de la notice
20/08/2019 13:45
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