Sentinel lymph node involvement and a high Breslow index are independent factors of risk for early relapse of melanoma.

Détails

ID Serval
serval:BIB_1590B88144A5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sentinel lymph node involvement and a high Breslow index are independent factors of risk for early relapse of melanoma.
Périodique
Nuklearmedizin. Nuclear medicine
Auteur(s)
Willi J.P., Matter M., Buchegger F., Antonescu C., Guggisberg D., Cerottini J.P., Krischer J., Braun R., Marie Kurt A., Roche B., Lemoine R., Rimoldi D., Lejeune F.J., Liénard D., Bischof Delaloye A.
ISSN
0029-5566
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
46
Numéro
6
Pages
244-251
Langue
anglais
Résumé
AIM: The clinical relevance of sentinel lymph node (SLN) analysis was evaluated prospectively and compared with other known risk factors of relapse in early stage melanoma. METHODS: Surgery was guided by lymphoscintigraphy, blue dye and gamma probe detection. SLN were analysed by haematoxylin eosin (HE) histochemistry and multimarker immunohistochemistry (IHC). Disease free survival (DFS) was evaluated with Kaplan-Meier plots according to different parameters and Cox analyses of variance. RESULTS: From 210 patients a total of 381 SLN were excised. Lymphoscintigraphy identified all excised SLN with only 2 false positive lymphatic lakes. Fifty patients (24%) had tumour positive SLN. With a mean follow-up of 31.3 months, 29 tumour recurrences were observed, 19 (38%) in 50 SLN positive and 10 (6%) in 160 SLN negative patients. Strong predictive factors for early relapse (p < 0.0005) were SLN positivity and a high Breslow index. CONCLUSION: SLN tumour positivity is an independent factor of high risk for early relapse with a higher power of discrimination than the Breslow index.
Mots-clé
Adolescent, Adult, Aged, Female, Humans, Male, Melanoma, Middle Aged, Neoplasm Metastasis, Recurrence, Risk Factors, Sentinel Lymph Node Biopsy, Survival Analysis
Pubmed
Web of science
Création de la notice
26/03/2009 14:57
Dernière modification de la notice
20/08/2019 12:44
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